Nucleoporin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:08, 11 November 2019) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
<StructureSection load='1xip' size='350' side='right' caption='Yeast nucleoporin NUP159 N-terminal domain (PDB entry [[1xip]])' scene='Nucleoporin/Cv/1'>
+
<StructureSection load='' size='350' side='right' caption='Yeast nucleoporin NUP159 N-terminal domain (PDB entry [[1xip]])' scene='Nucleoporin/Cv/1'>
== Function ==
== Function ==
[[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)<ref>PMID:9159086</ref>. <br />
[[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)<ref>PMID:9159086</ref>. <br />
Line 8: Line 8:
== Disease ==
== Disease ==
NUP98 and NUP214 gene translocation is associated with myeloid and lymphoid malignancies. NUP88 is over expressed in ovarian tumors. NUP214 is the functional receptor of adenovirus 2 nucleocapsids<ref>PMID:14693424</ref>.
NUP98 and NUP214 gene translocation is associated with myeloid and lymphoid malignancies. NUP88 is over expressed in ovarian tumors. NUP214 is the functional receptor of adenovirus 2 nucleocapsids<ref>PMID:14693424</ref>.
-
</StructureSection>
+
 
== 3D Structures of Nucleoporin ==
== 3D Structures of Nucleoporin ==
 +
[[Nucleoporin 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
*NUP2
+
-
**[[3n7c]] – NUP2 RANBD – ''Ashbya gossypii''<br />
+
-
**[[2c1t]] – yNUP2 NTD +importrin alpha subunit - yeast<br />
+
-
*NUP35
+
-
**[[1wwh]] – mNUP35 MPPN domain - mouse<br />
+
-
*NUP37
+
-
**[[4fhl]] – fyNUP37 – fission yeast<br />
+
-
**[[4fhm]], [[4fhn]], [[4gq2]] - fyNUP37 + NUP120<br />
+
-
*NUP43
+
-
**[[4i79]] – hNUP43 + polypeptide<br />
+
-
*NUP50
+
-
**[[2ec1]] – hNUP50 RANBD - human<br />
+
-
**[[2c1m]] – mNUP50 NTD +importin <br />
+
-
**[[3tj3]] - hNUP50 NTD+importin<br />
+
-
*NUP53
+
-
**[[3p3d]] - NUP53 RRM domain - ''Pischia guillermondii''<br />
+
-
**[[4lir]] – hNUP53 residues 151-266<br />
+
-
**[[5hb8]], [[5hb7]] – CtNUP53 - ''Chaetomium thermophilum''<br />
+
-
**[[5hb3]] – CtNUP53 + NUP NIC96 <br />
+
-
*NUP54
+
-
**[[3t97]] – rNUP54 + NUP62 - rat<br />
+
-
**[[4j3h]] – rNUP54 (mutant)<br />
+
-
**[[3t98]] – rNUP54 + rNUP58/45 <br />
+
-
**[[4jo7]], [[4jo9]] – hNUP54 + hNUP58/45 <br />
+
-
*NUP58
+
-
**[[2osz]] – rNUP58/45 <br />
+
-
**[[4jq5]] – hNUP58/45 <br />
+
-
*NUP82
+
-
**[[3pbp]] – yNUP82 NTD + NUP116 CTD + NUP159 CTD<br />
+
-
**[[3tkn]] - yNUP82 NTD + NUP98 + NUP159 CTD<br />
+
-
**[[5cww]] – CtNUP82 + CtNUP145 CTD peptide + Ct159 CTD peptide<br />
+
-
*NUP84
+
-
**[[3jro]], [[3iko]] – yNUP84+NUP145+protein Sec13<br />
+
-
**[[4xmm]] - yNUP84+NUP85+NUP120+NUP145+protein Seh1 + antibody<br />
+
-
**[[4xmn]] - yNUP84+NUP85+NUP120+NUP145 + antibody<br />
+
-
*NUP85
+
-
**[[3f3f]], [[3f3g]], [[3f3p]], [[3ewe]] – yNUP85+Seh1<br />
+
-
*NUP98
+
-
**[[3mmy]] – hNUP98 fragment+mRNA export factor <br />
+
-
**[[2q5x]], [[2q5y]] – hNUP98 CTD<br />
+
-
**[[1ko6]] – hNUP98 CTD<br />
+
-
*NUP100
+
-
**[[3nf5]] – NUP100 CTD – ''Candida glabrata''<br />
+
-
*NUP107
+
-
**[[3i4r]], [[3cqc]], [[3cqg]] – hNUP107+NUP133<br />
+
-
*NUP116
+
-
**[[2aiv]] – yNUP116 CTD - NMR<br />
+
-
*NUP120
+
-
**[[3f7f]], [[3h7n]], [[3hxr]] – yNUP120<br />
+
-
*NUP133
+
-
**[[1xks]], [[4q9t]] – hNUP133 NTD<br />
+
-
**[[3kfo]] – yNUP133 CTD <br />
+
-
*NUP145
+
-
**[[3bg0]], [[3bg1]] – hNUP145+Sec13-related protein<br />
+
-
**[[3kep]], [[3kes]] – yNUP145 autoproteolytic domain<br />
+
-
**[[3jrp]] - yNUP145+protein Sec13<br />
+
-
**[[5hb5]] – CtNUP145 <br />
+
-
**[[5hb6]] – CtNUP145 (mutant)<br />
+
-
*NUP152
+
-
**[[5tvz]] – yNUP152 Ig-like repeats - NMR<br />
+
-
*NUP153
+
-
**[[3gj3]], [[3gj4]], [[3gj5]], [[3gj6]], [[3gj7]], [[3gj8]], [[3ch5]] – hNUP153+RAN<br />
+
-
**[[2ebq]], [[2ebr]], [[2ebv]], [[2gqe]] - hNUP153 RANBD – NMR<br />
+
-
**[[2k0c]] – rNUP153 RANBD – NMR<br />
+
-
*NUP157
+
-
**[[4mhc]] – hNUP157 NTD<br />
+
-
*NUP159
+
-
**[[1xip]] – yNUP159 NTD<br />
+
-
**[[3rrm]] – yNUP159 residues 2-387 + NUP Gle1 + IP6 + ADP<br />
+
-
*NUP170
+
-
**[[3i5p]], [[3i5q]] – yNUP170<br />
+
-
**[[5hb1]] – CtNUP170 <br />
+
-
**[[5haz]] – CtNUP170 CTD<br />
+
-
**[[5hay]] – CtNUP170 CTD (mutant)<br />
+
-
**[[5hb0]] – CtNUP170 (mutant) + CtNUP145 peptide<br />
+
-
**[[5hax]] – CtNUP170 NTD + CtNUP53 peptide<br />
+
-
*NUP192
+
-
**[[4ifq]] – yNUP192<br />
+
-
**[[5hb4]] – CtNUP192 <br />
+
-
*NUP214
+
-
**[[3fmo]], [[3fmp]], [[3fhc]] – hNUP214+dead-box helicase<br />
+
-
**[[2oit]] – hNUP214 NTD<br />
+
-
*NUP358
+
-
**[[1z5s]] – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN CTD<br />
+
-
**[[1xke]] - hNUP358 RANBD - NMR<br />
+
-
*NUP1P
+
-
**[[5owu]] – yNUP1P+importin β subunit<br />
+
-
*NUP2P
+
-
**[[1un0]] – yNUP2P NTD+importrin α subunit<br />
+
-
*NUP-NSP1
+
-
**[[1o6o]] – yNUP-NSP1 residues 497-608+importrin β subunit<br />
+
-
*NUP-CDC31
+
-
**[[2doq]], [[2gv5]] – yNUP-CDC31+SFI1P<br />
+
-
**[[3fwb]], [[3fwc]] - yNUP-CDC31+SAC3<br />
+
-
 
+
-
*NUP Gle1
+
-
**[[3peu]], [[3pev]], [[3rrn]]– yNUP-Gle1 + ATP-dependent RNA helicase Dbp5 (mutant) +IP6
+
-
 
+
-
**[[2rfo]], [[2qx5]] – yNic96<br />
+
-
**[[5hb2]] – CtNic96 <br />
+
-
**[[1gyb]] – NUP+yNTF2<br />
+
-
}}
+
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Yeast nucleoporin NUP159 N-terminal domain (PDB entry 1xip)

Drag the structure with the mouse to rotate

References

  1. ↑ Doye V, Hurt E. From nucleoporins to nuclear pore complexes. Curr Opin Cell Biol. 1997 Jun;9(3):401-11. PMID:9159086
  2. ↑ Belanger KD, Kenna MA, Wei S, Davis LI. Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p. J Cell Biol. 1994 Aug;126(3):619-30. PMID:8045927
  3. ↑ Solsbacher J, Maurer P, Vogel F, Schlenstedt G. Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha. Mol Cell Biol. 2000 Nov;20(22):8468-79. PMID:11046143
  4. ↑ Cronshaw JM, Matunis MJ. The nuclear pore complex: disease associations and functional correlations. Trends Endocrinol Metab. 2004 Jan-Feb;15(1):34-9. PMID:14693424

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Nucleoporin"
Personal tools