A-kinase anchor protein

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<StructureSection load='4zp3' size='340' side='right' caption='Human AKAP18 helix (olive) complex with a dimer of cAMP-dependent protein kinase regulatory subunit (grey and green) and Cd+2 ions (PDB code [[4zp3]])' scene=''>
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<StructureSection load='4zp3' size='340' side='right' caption='Human AKAP18 helix (deepskyblue) complex with a dimer of cAMP-dependent protein kinase regulatory subunit (magenta and green) and Cd+2 ions (PDB code [[4zp3]])' scene='77/777613/Cv/2'>
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'''A-kinase anchor proteins''' (AKAP) mediate the localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes by interacting with them <ref>PMID:10712918</ref>.
'''A-kinase anchor proteins''' (AKAP) mediate the localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes by interacting with them <ref>PMID:10712918</ref>.
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AKAPs form multi-protein complexes via interaction with the regulatory subunits of PKA. These protein complexes are key molecules in the biochemical machinery regulating the function of flagella and cilia<ref>PMID:17566268</ref>.
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AKAPs form multi-protein complexes via interaction with the regulatory subunits of PKA. These protein complexes are key molecules in the biochemical machinery regulating the function of flagella and cilia<ref>PMID:17566268</ref>. '''A-kinase anchor protein 10''' is also named '''dual specificity A-kinase anchor protein 2'''.
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*'''Small membrane A-kinase anchor protein''' (smAKAP) is localised at the plasma membrane<ref>PMID:23115245</ref>.
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== Disease ==
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== Relevance ==
== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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An ampiphatic helix of AKAP18 binds with its hydrophobic sides to helices of the PKA regulatory subunit<ref>PMID:27102985</ref>.
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An <scene name='77/777613/Cv/5'>ampiphatic helix of AKAP18 binds with its hydrophobic sides to helices of the PKA regulatory subunit</scene><ref>PMID:27102985</ref>. {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}
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</StructureSection>
 
== 3D Structures of A-kinase anchor protein ==
== 3D Structures of A-kinase anchor protein ==
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[[A-kinase anchor protein 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*A-kinase anchor protein 10
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**[[3tmh]] – hAKAP10 A-kinase-binding domain + cAMP-dependent protein kinase type II-alpha regulatory subunit + NHERF-3 <br />
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*A-kinase anchor protein 13
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**[[4d0o]] – hAKAP13 DH domain – human <br />
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**[[4d0n]] – hAKAP13 DH domain + RhoA<br />
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**[[2lg1]] – hAKAP13 PH domain - NMR<br />
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**[[6bca]] – hAKAP13 PH domain + RhoA + GTP analog<br />
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*A-kinase anchor protein 18
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**[[5jj2]] – hAKAP18 2H phosphoestease domain <br />
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**[[2vfl]] – hAKAP18 2H phosphoestease domain + CMP<br />
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**[[3j4q]], [[3j4r]] – hAKAP18 residues 1-353 + cAMP-dependent protein kinase type II-alpha regulatory subunit + PKA C-alpha – Cryo EM <br />
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**[[4zp3]] – hAKAP18 residues 43-82 + cAMP-dependent protein kinase type II-alpha regulatory subunit <br />
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*Small membrane A-kinase anchor protein
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**[[5hvz]] – hsmAKAP A-kinase-binding domain + cAMP-dependent protein kinase type II-alpha regulatory subunit <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human AKAP18 helix (deepskyblue) complex with a dimer of cAMP-dependent protein kinase regulatory subunit (magenta and green) and Cd+2 ions (PDB code 4zp3)

Drag the structure with the mouse to rotate

References

  1. ↑ Edwards AS, Scott JD. A-kinase anchoring proteins: protein kinase A and beyond. Curr Opin Cell Biol. 2000 Apr;12(2):217-21. PMID:10712918
  2. ↑ Carr DW, Newell AE. The role of A-kinase anchoring proteins (AKaps) in regulating sperm function. Soc Reprod Fertil Suppl. 2007;63:135-41. PMID:17566268
  3. ↑ Burgers PP, Ma Y, Margarucci L, Mackey M, van der Heyden MA, Ellisman M, Scholten A, Taylor SS, Heck AJ. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. J Biol Chem. 2012 Dec 21;287(52):43789-97. doi: 10.1074/jbc.M112.395970. Epub, 2012 Oct 31. PMID:23115245 doi:http://dx.doi.org/10.1074/jbc.M112.395970
  4. ↑ Diviani D, Dodge-Kafka KL, Li J, Kapiloff MS. A-kinase anchoring proteins: scaffolding proteins in the heart. Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1742-53. doi:, 10.1152/ajpheart.00569.2011. Epub 2011 Aug 19. PMID:21856912 doi:http://dx.doi.org/10.1152/ajpheart.00569.2011
  5. ↑ Gotz F, Roske Y, Schulz MS, Autenrieth K, Bertinetti D, Faelber K, Zuhlke K, Kreuchwig A, Kennedy E, Krause G, Daumke O, Herberg FW, Heinemann U, Klussmann E. AKAP18:PKA-RIIalpha structure reveals crucial anchor points for recognition of regulatory subunits of PKA. Biochem J. 2016 Apr 21. pii: BCJ20160242. PMID:27102985 doi:http://dx.doi.org/10.1042/BCJ20160242

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