5yqm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:24, 27 March 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5yqm is ON HOLD until Paper Publication
+
==Crystal structure of Sirt2 in complex with selective inhibitor A29==
 +
<StructureSection load='5yqm' size='340' side='right'caption='[[5yqm]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5yqm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YQM FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.735&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2X:2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-(4-phenylsulfanylphenyl)ethanamide'>A2X</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yqm OCA], [https://pdbe.org/5yqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yqm RCSB], [https://www.ebi.ac.uk/pdbsum/5yqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yqm ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref>
-
Authors: Wang, H., Yu, Y., Li, G., chen, Q.
+
==See Also==
-
 
+
*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
-
Description: Crystal structure of Sirt2 in complex with selective inhibitor A29
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Chen, Q]]
+
__TOC__
-
[[Category: Li, G]]
+
</StructureSection>
-
[[Category: Wang, H]]
+
[[Category: Homo sapiens]]
-
[[Category: Yu, Y]]
+
[[Category: Large Structures]]
 +
[[Category: Li G]]
 +
[[Category: Wang H]]
 +
[[Category: Yu Y]]
 +
[[Category: Chen Q]]

Current revision

Crystal structure of Sirt2 in complex with selective inhibitor A29

PDB ID 5yqm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5yqm"
Personal tools