6bze

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'''Unreleased structure'''
 
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The entry 6bze is ON HOLD
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==Cryo-EM structure of BCL10 CARD filament==
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<SX load='6bze' size='340' side='right' viewer='molstar' caption='[[6bze]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6bze]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BZE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bze OCA], [https://pdbe.org/6bze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bze RCSB], [https://www.ebi.ac.uk/pdbsum/6bze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bze ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BCL10_HUMAN BCL10_HUMAN] A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. Defects in BCL10 are involved in various types of cancer. The gene represented in this entry may be involved in disease pathogenesis.
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== Function ==
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[https://www.uniprot.org/uniprot/BCL10_HUMAN BCL10_HUMAN] Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.<ref>PMID:18264101</ref>
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Authors:
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</SX>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: David L]]
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[[Category: Garner E]]
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[[Category: Li Y]]
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[[Category: Ma J]]
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[[Category: Wu H]]
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[[Category: Zhang X]]

Current revision

Cryo-EM structure of BCL10 CARD filament

6bze, resolution 4.00Å

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OCA

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