1fsc

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==Crystal Structure of Fasciculin 2 from Green Mamba Snake Venom: Evidence for Unusual Loop Flexibility==
==Crystal Structure of Fasciculin 2 from Green Mamba Snake Venom: Evidence for Unusual Loop Flexibility==
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<StructureSection load='1fsc' size='340' side='right' caption='[[1fsc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='1fsc' size='340' side='right'caption='[[1fsc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1fsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bmnh_1946.1.20.48 Bmnh 1946.1.20.48]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FSC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1fsc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FSC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fsc OCA], [http://pdbe.org/1fsc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fsc RCSB], [http://www.ebi.ac.uk/pdbsum/1fsc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fsc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fsc OCA], [https://pdbe.org/1fsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fsc RCSB], [https://www.ebi.ac.uk/pdbsum/1fsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fsc ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/3SE2_DENAN 3SE2_DENAN] Interferes with neuromuscular transmission by inhibiting the enzyme acetylcholinesterase (AChE) present at the neuromuscular junction. It selectively binds and inhibits with a 1:1 stoichiometry the mammalian and electric fish AChE at picomolar concentrations. It is highly specific for the peripheral site of AChE and blocks the entry of acetylcholine into the active site of the enzyme (through the Met-33 residue), thereby preventing its breakdown. It has been called fasciculin since after injection into mice it causes severe, generalized and long-lasting (5-7 hours) fasciculations.<ref>PMID:6530667</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fs/1fsc_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fs/1fsc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 1fsc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1fsc" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Fasciculin|Fasciculin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bmnh 1946 1.20 48]]
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[[Category: Dendroaspis angusticeps]]
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[[Category: Du, M H.Le]]
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[[Category: Large Structures]]
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[[Category: Fontecilla-Camps, J C]]
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[[Category: Fontecilla-Camps JC]]
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[[Category: Housset, D]]
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[[Category: Housset D]]
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[[Category: Snake toxin]]
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[[Category: Le Du MH]]

Current revision

Crystal Structure of Fasciculin 2 from Green Mamba Snake Venom: Evidence for Unusual Loop Flexibility

PDB ID 1fsc

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