2cy6

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[[Image:2cy6.gif|left|200px]]
 
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{{Structure
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==Crystal structure of ConM in complex with trehalose and maltose==
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|PDB= 2cy6 |SIZE=350|CAPTION= <scene name='initialview01'>2cy6</scene>, resolution 2.00&Aring;
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<StructureSection load='2cy6' size='340' side='right'caption='[[2cy6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TRE:TREHALOSE'>TRE</scene>
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<table><tr><td colspan='2'>[[2cy6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CY6 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PRD_900006:trehalose'>PRD_900006</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cy6 OCA], [https://pdbe.org/2cy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cy6 RCSB], [https://www.ebi.ac.uk/pdbsum/2cy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cy6 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2cwm|2CWM]], [[2cyf|2CYF]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cy6 OCA], [http://www.ebi.ac.uk/pdbsum/2cy6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cy6 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CONA_CANLI CONA_CANLI] Glucose/D-mannose specific lectin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/2cy6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cy6 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of ConM in complex with trehalose and maltose'''
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==See Also==
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*[[Concanavalin 3D structures|Concanavalin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The crystal structure of Canavalia maritima lectin (ConM) complexed with trehalose and maltose revealed relevant point mutations in ConA-like lectins. ConM with the disaccharides and other ConA-like lectins complexed with carbohydrates demonstrated significant differences in the position of H-bonds. The main difference in the ConM structure is the replacement of Pro202 by Ser202, a residue that promotes the approximation of Tyr12 to the carbohydrate-binding site. The O-6' of the second glucose ring in maltose interacts with Tyr12, while in trehalose the interaction is established by the O-2' and Tyr12, explaining the higher affinity of ConM for disaccharides compared to monosaccharides.
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[[Category: Canavalia rosea]]
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Azevedo Jr WF]]
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2CY6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Canavalia_maritima Canavalia maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CY6 OCA].
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[[Category: Cavada BS]]
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[[Category: Delatorre P]]
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==Reference==
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[[Category: Gadelha CAA]]
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Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins., Delatorre P, Rocha BA, Gadelha CA, Santi-Gadelha T, Cajazeiras JB, Souza EP, Nascimento KS, Freire VN, Sampaio AH, Azevedo WF Jr, Cavada BS, J Struct Biol. 2006 Jun;154(3):280-6. Epub 2006 Apr 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16677825 16677825]
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[[Category: Rocha BAM]]
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[[Category: Canavalia maritima]]
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[[Category: Souza EP]]
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[[Category: Protein complex]]
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[[Category: Cavada, B S.]]
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[[Category: Delatorre, P.]]
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[[Category: Gadelha, C A.A.]]
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[[Category: Jr., W F.Azevedo.]]
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[[Category: Rocha, B A.M.]]
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[[Category: Souza, E P.]]
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[[Category: canavalia maritima]]
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[[Category: lectin]]
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[[Category: trehalose]]
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[[Category: x-ray diffraction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:27:55 2008''
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Current revision

Crystal structure of ConM in complex with trehalose and maltose

PDB ID 2cy6

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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