2d00

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[[Image:2d00.gif|left|200px]]
 
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{{Structure
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==Subunit F of V-type ATPase/synthase==
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|PDB= 2d00 |SIZE=350|CAPTION= <scene name='initialview01'>2d00</scene>, resolution 2.2&Aring;
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<StructureSection load='2d00' size='340' side='right'caption='[[2d00]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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<table><tr><td colspan='2'>[[2d00]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D00 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d00 OCA], [https://pdbe.org/2d00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d00 RCSB], [https://www.ebi.ac.uk/pdbsum/2d00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d00 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d00 OCA], [http://www.ebi.ac.uk/pdbsum/2d00 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2d00 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/VATF_THET8 VATF_THET8] Produces ATP from ADP in the presence of a proton gradient across the membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/2d00_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d00 ConSurf].
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<div style="clear:both"></div>
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'''Subunit F of V-type ATPase/synthase'''
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==See Also==
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*[[ATPase 3D structures|ATPase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The crystal structure of subunit F of vacuole-type ATPase/synthase (prokaryotic V-ATPase) was determined to of 2.2 A resolution. The subunit reveals unexpected structural similarity to the response regulator proteins that include the Escherichia coli chemotaxis response regulator CheY. The structure was successfully placed into the low-resolution EM structure of the prokaryotic holo-V-ATPase at a location indicated by the results of crosslinking experiments. The crystal structure, together with the single-molecule analysis using fluorescence resonance energy transfer, showed that the subunit F exhibits two conformations, a 'retracted' form in the absence and an 'extended' form in the presence of ATP. Our results postulated that the subunit F is a regulatory subunit in the V-ATPase.
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[[Category: Large Structures]]
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==About this Structure==
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2D00 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D00 OCA].
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==Reference==
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Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus., Makyio H, Iino R, Ikeda C, Imamura H, Tamakoshi M, Iwata M, Stock D, Bernal RA, Carpenter EP, Yoshida M, Yokoyama K, Iwata S, EMBO J. 2005 Nov 16;24(22):3974-83. Epub 2005 Nov 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16281059 16281059]
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[[Category: H(+)-transporting two-sector ATPase]]
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[[Category: Single protein]]
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[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Bernal, R A.]]
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[[Category: Bernal RA]]
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[[Category: Carpenter, E P.]]
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[[Category: Carpenter EP]]
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[[Category: Iino, R.]]
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[[Category: Iino R]]
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[[Category: Ikeda, C.]]
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[[Category: Ikeda C]]
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[[Category: Imamura, H.]]
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[[Category: Imamura H]]
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[[Category: Iwata, M.]]
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[[Category: Iwata M]]
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[[Category: Iwata, S.]]
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[[Category: Iwata S]]
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[[Category: Makyio, H.]]
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[[Category: Makyio H]]
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[[Category: Stock, D.]]
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[[Category: Stock D]]
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[[Category: Tamakoshi, M.]]
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[[Category: Tamakoshi M]]
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[[Category: Yokoyama, K.]]
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[[Category: Yokoyama K]]
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[[Category: Yoshida, M.]]
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[[Category: Yoshida M]]
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[[Category: chey]]
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[[Category: fret]]
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[[Category: subunit f]]
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[[Category: v-atpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:28:30 2008''
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Current revision

Subunit F of V-type ATPase/synthase

PDB ID 2d00

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