5z2q
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5z2q is ON HOLD Authors: Pobbati, A.V., Song, H. Description: Vgll1-TEAD4 core complex Category: Unreleased Structures Category: Song, H [[...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Vgll1-TEAD4 core complex== | |
| + | <StructureSection load='5z2q' size='340' side='right'caption='[[5z2q]], [[Resolution|resolution]] 2.74Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5z2q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4eaz 4eaz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z2Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z2q OCA], [https://pdbe.org/5z2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z2q RCSB], [https://www.ebi.ac.uk/pdbsum/5z2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z2q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VGLL1_MOUSE VGLL1_MOUSE] May act as a specific coactivator for the mammalian TEFs (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian equivalent of the Drosophila Vestigial and Scalloped, respectively, is determined in this study. Remarkably, Vgll1 interacts with TEAD in a manner similar to the transcription coactivators, as well as oncogenes YAP and TAZ, despite having a varied primary sequence. Vgll1-TEAD complex upregulates the expression of IGFBP-5, a proliferation-promoting gene, and facilitates anchorage-independent cell proliferation. The YAP/TAZ-TEAD complex also upregulates several other proliferation-promoting genes and also promotes anchorage-independent cell proliferation. Given its structural and functional similarity to YAP/TAZ, Vgll1 has the potential to promote cancer progression. | ||
| - | + | Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.,Pobbati AV, Chan SW, Lee I, Song H, Hong W Structure. 2012 Jul 3;20(7):1135-40. Epub 2012 May 24. PMID:22632831<ref>PMID:22632831</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5z2q" style="background-color:#fffaf0;"></div> |
| - | [[Category: Pobbati | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Pobbati AV]] | ||
| + | [[Category: Song H]] | ||
Current revision
Vgll1-TEAD4 core complex
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