5wi0

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==Crystal structure of human NAMPT with fragment 2: 2-[(2-fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one==
==Crystal structure of human NAMPT with fragment 2: 2-[(2-fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one==
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<StructureSection load='5wi0' size='340' side='right' caption='[[5wi0]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='5wi0' size='340' side='right'caption='[[5wi0]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wi0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WI0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wi0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WI0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AQ1:2-[(2-fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one'>AQ1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AQ1:2-[(2-fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one'>AQ1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wi0 OCA], [http://pdbe.org/5wi0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wi0 RCSB], [http://www.ebi.ac.uk/pdbsum/5wi0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wi0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wi0 OCA], [https://pdbe.org/5wi0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wi0 RCSB], [https://www.ebi.ac.uk/pdbsum/5wi0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wi0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
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[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5wi0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5wi0" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Nicotinamide phosphoribosyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Korepanova, A V]]
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[[Category: Large Structures]]
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[[Category: Longenecker, K L]]
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[[Category: Korepanova AV]]
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[[Category: Raich, D]]
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[[Category: Longenecker KL]]
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[[Category: Inhibitor]]
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[[Category: Raich D]]
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[[Category: Nampt]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of human NAMPT with fragment 2: 2-[(2-fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one

PDB ID 5wi0

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