6b0b
From Proteopedia
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==Crystal structure of human APOBEC3H== | ==Crystal structure of human APOBEC3H== | ||
| - | <StructureSection load='6b0b' size='340' side='right' caption='[[6b0b]], [[Resolution|resolution]] 3.28Å' scene=''> | + | <StructureSection load='6b0b' size='340' side='right'caption='[[6b0b]], [[Resolution|resolution]] 3.28Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6b0b]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6b0b]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Discosoma_sp. Discosoma sp.], [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B0B FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2800622Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b0b OCA], [https://pdbe.org/6b0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b0b RCSB], [https://www.ebi.ac.uk/pdbsum/6b0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b0b ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ABC3H_HUMAN ABC3H_HUMAN] DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms (PubMed:16571802, PubMed:16920826, PubMed:18779051, PubMed:18827027, PubMed:20062055, PubMed:22915799, PubMed:29290613). The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1 (PubMed:18299330, PubMed:21835787, PubMed:23097438, PubMed:29290613). After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:18299330). The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells (PubMed:18299330). Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA (PubMed:20062055). Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons (PubMed:20062055, PubMed:22457529).<ref>PMID:16571802</ref> <ref>PMID:16920826</ref> <ref>PMID:18299330</ref> <ref>PMID:18779051</ref> <ref>PMID:18827027</ref> <ref>PMID:20062055</ref> <ref>PMID:21835787</ref> <ref>PMID:22457529</ref> <ref>PMID:22915799</ref> <ref>PMID:23097438</ref> <ref>PMID:29290613</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6b0b" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6b0b" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Green Fluorescent Protein 3D structures|Green Fluorescent Protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Discosoma sp]] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Aihara | + | [[Category: Large Structures]] |
| - | [[Category: Banerjee | + | [[Category: Aihara H]] |
| - | [[Category: Harris | + | [[Category: Banerjee S]] |
| - | [[Category: Shaban | + | [[Category: Harris RS]] |
| - | [[Category: Shi | + | [[Category: Shaban NM]] |
| - | + | [[Category: Shi K]] | |
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Current revision
Crystal structure of human APOBEC3H
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