1hwk

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==COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH ATORVASTATIN==
==COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH ATORVASTATIN==
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<StructureSection load='1hwk' size='340' side='right' caption='[[1hwk]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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<StructureSection load='1hwk' size='340' side='right'caption='[[1hwk]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1hwk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. The December 2007 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Oxidosqualene Cyclase'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_12 10.2210/rcsb_pdb/mom_2007_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HWK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1hwk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The December 2007 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Oxidosqualene Cyclase'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2007_12 10.2210/rcsb_pdb/mom_2007_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HWK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=117:7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-+3,5-DIHYDROXY-HEPTANOIC+ACID'>117</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dq8|1dq8]], [[1dq9|1dq9]], [[1dqa|1dqa]], [[1hw8|1hw8]], [[1hw9|1hw9]], [[1hwi|1hwi]], [[1hwj|1hwj]], [[1hwl|1hwl]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=117:7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-+3,5-DIHYDROXY-HEPTANOIC+ACID'>117</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMGCR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hwk OCA], [https://pdbe.org/1hwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hwk RCSB], [https://www.ebi.ac.uk/pdbsum/1hwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hwk ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase_(NADPH) Hydroxymethylglutaryl-CoA reductase (NADPH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.34 1.1.1.34] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hwk OCA], [http://pdbe.org/1hwk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hwk RCSB], [http://www.ebi.ac.uk/pdbsum/1hwk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hwk ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN]] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
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[https://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Atorvastatin|Atorvastatin]]
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*[[HMG-CoA Reductase|HMG-CoA Reductase]]
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*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Oxidosqualene Cyclase]]
[[Category: Oxidosqualene Cyclase]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Deisenhofer, J]]
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[[Category: Deisenhofer J]]
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[[Category: Istvan, E S]]
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[[Category: Istvan ES]]
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[[Category: Oxidoreductase]]
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[[Category: Protein-inhibitor complex]]
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Current revision

COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH ATORVASTATIN

PDB ID 1hwk

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