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2d4z

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[[Image:2d4z.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the cytoplasmic domain of the chloride channel ClC-0==
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|PDB= 2d4z |SIZE=350|CAPTION= <scene name='initialview01'>2d4z</scene>, resolution 3.10&Aring;
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<StructureSection load='2d4z' size='340' side='right'caption='[[2d4z]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2d4z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Torpedo_marmorata Torpedo marmorata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D4Z FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d4z OCA], [https://pdbe.org/2d4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d4z RCSB], [https://www.ebi.ac.uk/pdbsum/2d4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d4z ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d4z OCA], [http://www.ebi.ac.uk/pdbsum/2d4z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2d4z RCSB]</span>
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[https://www.uniprot.org/uniprot/CICH_TORMA CICH_TORMA] Voltage-gated chloride channel. This channel is thought to ensure the high conductance of the non-innervated membrane of the electrocyte necessary for efficient current generation caused by sodium influx through the acetylcholine receptor at the innervated membrane.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d4/2d4z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d4z ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of the cytoplasmic domain of the chloride channel ClC-0'''
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Ion channels are frequently organized in a modular fashion and consist of a membrane-embedded pore domain and a soluble regulatory domain. A similar organization is found for the ClC family of Cl- channels and transporters. Here, we describe the crystal structure of the cytoplasmic domain of ClC-0, the voltage-dependent Cl- channel from T. marmorata. The structure contains a folded core of two tightly interacting cystathionine beta-synthetase (CBS) subdomains. The two subdomains are connected by a 96 residue mobile linker that is disordered in the crystals. As revealed by analytical ultracentrifugation, the domains form dimers, thereby most likely extending the 2-fold symmetry of the transmembrane pore. The structure provides insight into the organization of the cytoplasmic domains within the ClC family and establishes a framework for guiding future investigations on regulatory mechanisms.
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[[Category: Large Structures]]
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==About this Structure==
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2D4Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_marmorata Torpedo marmorata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D4Z OCA].
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==Reference==
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Crystal structure of the cytoplasmic domain of the chloride channel ClC-0., Meyer S, Dutzler R, Structure. 2006 Feb;14(2):299-307. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16472749 16472749]
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[[Category: Single protein]]
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[[Category: Torpedo marmorata]]
[[Category: Torpedo marmorata]]
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[[Category: Dutzler, R.]]
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[[Category: Dutzler R]]
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[[Category: Meyer, S.]]
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[[Category: Meyer S]]
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[[Category: cbs domain]]
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[[Category: clc chloride channel cytoplasmic domain]]
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[[Category: ion channel regulatory subunit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:30:22 2008''
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Current revision

Crystal structure of the cytoplasmic domain of the chloride channel ClC-0

PDB ID 2d4z

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