1ija

<StructureSection load='1ija' size='340' side='right' caption='[[1ija]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1ija]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IJA FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ija FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ija OCA], [http://pdbe.org/1ija PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ija RCSB], [http://www.ebi.ac.uk/pdbsum/1ija PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ija ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Surface proteins of Gram-positive bacteria play important roles during the pathogenesis of human infections and require sortase for anchoring to the cell-wall envelope. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine (T) and the amino group of cell-wall crossbridges. The NMR structure of sortase reveals a unique beta-barrel structure, in which the active-site sulfhydryl of cysteine-184 is poised for ionization by histidine-120, presumably enabling the resultant thiolate to attack the LPXTG peptide. Calcium binding near the active site stimulates catalysis, possibly by altering the conformation of a surface loop that recognizes newly translocated polypeptides. The structure suggests a mechanistic relationship to the papain/cathepsin proteases and should facilitate the design of new antiinfective agents.

Structure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureus.,Ilangovan U, Ton-That H, Iwahara J, Schneewind O, Clubb RT Proc Natl Acad Sci U S A. 2001 May 22;98(11):6056-61. PMID:11371637<ref>PMID:11371637</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1ija" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Clubb, R T]]

[[Category: Ilangovan, U]]

[[Category: Iwahara, J]]

[[Category: Schneewind, O]]

[[Category: Ton-That, H]]

[[Category: Eight stranded beta barrel]]

[[Category: Protein binding]]

[[Category: Transpeptidase]]