5svh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:48, 4 October 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5svh is ON HOLD until Apr 26 2019
+
==Crystal structure of the KIX domain of CBP in complex with a MLL/c-Myb chimera==
-
 
+
<StructureSection load='5svh' size='340' side='right'caption='[[5svh]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-
Authors: Langelaan, D.N., Smith, S.P., Allingham, J.A.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5svh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SVH FirstGlance]. <br>
-
Description: Crystal structure of the KIX domain of CBP in complex with a MLL/c-Myb chimera
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
[[Category: Langelaan, D.N]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5svh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5svh OCA], [https://pdbe.org/5svh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5svh RCSB], [https://www.ebi.ac.uk/pdbsum/5svh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5svh ProSAT]</span></td></tr>
-
[[Category: Allingham, J.A]]
+
</table>
-
[[Category: Smith, S.P]]
+
== Disease ==
 +
[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[https://omim.org/entry/180849 180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Gallus gallus]]
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Allingham JA]]
 +
[[Category: Langelaan DN]]
 +
[[Category: Smith SP]]

Current revision

Crystal structure of the KIX domain of CBP in complex with a MLL/c-Myb chimera

PDB ID 5svh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5svh"
Personal tools