5wy0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:19, 20 March 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of the methyltranferase domain of human HEN1 in complex with AdoMet==
==Crystal structure of the methyltranferase domain of human HEN1 in complex with AdoMet==
-
<StructureSection load='5wy0' size='340' side='right' caption='[[5wy0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+
<StructureSection load='5wy0' size='340' side='right'caption='[[5wy0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5wy0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WY0 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5wy0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WY0 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.001&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wy0 OCA], [http://pdbe.org/5wy0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wy0 RCSB], [http://www.ebi.ac.uk/pdbsum/5wy0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wy0 ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wy0 OCA], [https://pdbe.org/5wy0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wy0 RCSB], [https://www.ebi.ac.uk/pdbsum/5wy0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wy0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/HENMT_HUMAN HENMT_HUMAN]] Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity).
+
[https://www.uniprot.org/uniprot/HENMT_HUMAN HENMT_HUMAN] Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity).
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Huang, Y]]
+
[[Category: Homo sapiens]]
-
[[Category: Ma, J B]]
+
[[Category: Large Structures]]
-
[[Category: Peng, L]]
+
[[Category: Huang Y]]
-
[[Category: Wu, L G]]
+
[[Category: Ma JB]]
-
[[Category: Adomet]]
+
[[Category: Peng L]]
-
[[Category: Rna methyltranferase]]
+
[[Category: Wu LG]]
-
[[Category: Transferase]]
+

Current revision

Crystal structure of the methyltranferase domain of human HEN1 in complex with AdoMet

PDB ID 5wy0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools