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2jau

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==Crystal structure of D41N variant of human mitochondrial 5'(3')- deoxyribonucleotidase (mdN) in complex with 3'-azidothymidine 5'- monophosphate==
==Crystal structure of D41N variant of human mitochondrial 5'(3')- deoxyribonucleotidase (mdN) in complex with 3'-azidothymidine 5'- monophosphate==
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<StructureSection load='2jau' size='340' side='right' caption='[[2jau]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='2jau' size='340' side='right'caption='[[2jau]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jau]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JAU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATM:3-AZIDO-3-DEOXYTHYMIDINE-5-MONOPHOSPHATE'>ATM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mh9|1mh9]], [[1q91|1q91]], [[1q92|1q92]], [[1z4i|1z4i]], [[1z4j|1z4j]], [[1z4k|1z4k]], [[1z4l|1z4l]], [[1z4m|1z4m]], [[1z4p|1z4p]], [[1z4q|1z4q]], [[2jaw|2jaw]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATM:3-AZIDO-3-DEOXYTHYMIDINE-5-MONOPHOSPHATE'>ATM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jau OCA], [http://pdbe.org/2jau PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jau RCSB], [http://www.ebi.ac.uk/pdbsum/2jau PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jau ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jau OCA], [https://pdbe.org/2jau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jau RCSB], [https://www.ebi.ac.uk/pdbsum/2jau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jau ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN]] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
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[https://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bianchi, V]]
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[[Category: Large Structures]]
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[[Category: Nordlund, P]]
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[[Category: Bianchi V]]
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[[Category: Ruzzenente, B]]
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[[Category: Nordlund P]]
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[[Category: Wallden, K]]
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[[Category: Ruzzenente B]]
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[[Category: Alfa beta fold]]
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[[Category: Wallden K]]
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[[Category: Hydrolase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Mitochondrial]]
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[[Category: Mitochondrion]]
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[[Category: Nucleotide metabolism]]
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[[Category: Nucleotide- binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Transit peptide]]
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Current revision

Crystal structure of D41N variant of human mitochondrial 5'(3')- deoxyribonucleotidase (mdN) in complex with 3'-azidothymidine 5'- monophosphate

PDB ID 2jau

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