2uvl

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==Human BIR3 domain of Baculoviral Inhibitor of Apoptosis Repeat- Containing 3 (BIRC3)==
==Human BIR3 domain of Baculoviral Inhibitor of Apoptosis Repeat- Containing 3 (BIRC3)==
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<StructureSection load='2uvl' size='340' side='right' caption='[[2uvl]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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<StructureSection load='2uvl' size='340' side='right'caption='[[2uvl]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2uvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UVL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2uvl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UVL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvl OCA], [http://pdbe.org/2uvl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uvl RCSB], [http://www.ebi.ac.uk/pdbsum/2uvl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uvl ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvl OCA], [https://pdbe.org/2uvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uvl RCSB], [https://www.ebi.ac.uk/pdbsum/2uvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uvl ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BIRC3_HUMAN BIRC3_HUMAN] Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
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== Function ==
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[https://www.uniprot.org/uniprot/BIRC3_HUMAN BIRC3_HUMAN] Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.<ref>PMID:21931591</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C]]
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[[Category: Large Structures]]
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[[Category: Berg, S Van Den]]
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[[Category: Arrowsmith C]]
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[[Category: Berglund, H]]
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[[Category: Berglund H]]
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[[Category: Busam, R]]
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[[Category: Busam R]]
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[[Category: Collins, R]]
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[[Category: Collins R]]
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[[Category: Dahlgren, L G]]
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[[Category: Dahlgren LG]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Flodin, S]]
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[[Category: Flodin S]]
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[[Category: Flores, A]]
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[[Category: Flores A]]
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[[Category: Graslund, S]]
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[[Category: Graslund S]]
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[[Category: Hallberg, B M]]
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[[Category: Hallberg BM]]
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[[Category: Hammarstrom, M]]
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[[Category: Hammarstrom M]]
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[[Category: Holmberg-Schiavone, L]]
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[[Category: Holmberg-Schiavone L]]
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[[Category: Johansson, I]]
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[[Category: Johansson I]]
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[[Category: Karlberg, T]]
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[[Category: Karlberg T]]
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[[Category: Kotenyova, T]]
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[[Category: Kotenyova T]]
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[[Category: Lehtio, L]]
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[[Category: Lehtio L]]
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[[Category: Moche, M]]
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[[Category: Moche M]]
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[[Category: Nordlund, P]]
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[[Category: Nordlund P]]
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[[Category: Nyman, T]]
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[[Category: Nyman T]]
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[[Category: Ogg, D]]
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[[Category: Ogg D]]
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[[Category: Persson, C]]
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[[Category: Persson C]]
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[[Category: Sagemark, J]]
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[[Category: Sagemark J]]
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[[Category: Stenmark, P]]
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[[Category: Stenmark P]]
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[[Category: Sundstrom, M]]
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[[Category: Sundstrom M]]
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[[Category: Thorsell, A G]]
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[[Category: Thorsell AG]]
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[[Category: Upsten, M]]
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[[Category: Upsten M]]
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[[Category: Weigelt, J]]
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[[Category: Van Den Berg S]]
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[[Category: Apoptosis]]
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[[Category: Weigelt J]]
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[[Category: Chromosomal rearrangement]]
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[[Category: Focal adhesion]]
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[[Category: Metal binding protein]]
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[[Category: Metal-binding]]
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[[Category: Metal-binding protein]]
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[[Category: Polymorphism]]
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[[Category: Zinc]]
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[[Category: Zinc finger]]
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[[Category: Zinc-finger]]
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Current revision

Human BIR3 domain of Baculoviral Inhibitor of Apoptosis Repeat- Containing 3 (BIRC3)

PDB ID 2uvl

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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