2vaj

From Proteopedia

(Difference between revisions)

Current revision

Crystal structure of NCAM2 Ig1 (I4122 cell unit)

Structural highlights

2vaj is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.701Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NCAM2_HUMAN May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of the first immunoglobulin (Ig1) domain of neural cell adhesion molecule 2 (NCAM2/OCAM/RNCAM) is presented at a resolution of 2.7 A. NCAM2 is a member of the immunoglobulin superfamily of cell adhesion molecules (IgCAMs). In the structure, two Ig domains interact by domain swapping, as the two N-terminal beta-strands are interchanged. beta-Strand swapping at the terminal domain is the accepted mechanism of homophilic interactions amongst the cadherins, another class of CAMs, but it has not been observed within the IgCAM superfamily. Gel-filtration chromatography demonstrated the ability of NCAM2 Ig1 to form dimers in solution. Taken together, these observations suggest that beta-strand swapping could have a role in the molecular mechanism of homophilic binding for NCAM2.

Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.,Rasmussen KK, Kulahin N, Kristensen O, Poulsen JC, Sigurskjold BW, Kastrup JS, Berezin V, Bock E, Walmod PS, Gajhede M J Mol Biol. 2008 Oct 24;382(5):1113-20. Epub 2008 Aug 6. PMID:18706912^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Rasmussen KK, Kulahin N, Kristensen O, Poulsen JC, Sigurskjold BW, Kastrup JS, Berezin V, Bock E, Walmod PS, Gajhede M. Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping. J Mol Biol. 2008 Oct 24;382(5):1113-20. Epub 2008 Aug 6. PMID:18706912 doi:http://dx.doi.org/10.1016/j.jmb.2008.07.084

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vaj"

@@ Line 1: / Line 1: @@
 ==Crystal structure of NCAM2 Ig1 (I4122 cell unit)==
-<StructureSection load='2vaj' size='340' side='right' caption='[[2vaj]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+<StructureSection load='2vaj' size='340' side='right'caption='[[2vaj]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2vaj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VAJ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2vaj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VAJ FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v5t|2v5t]], [[2doc|2doc]], [[2v44|2v44]], [[2va4|2va4]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.701&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vaj OCA], [http://pdbe.org/2vaj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vaj RCSB], [http://www.ebi.ac.uk/pdbsum/2vaj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vaj ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vaj OCA], [https://pdbe.org/2vaj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vaj RCSB], [https://www.ebi.ac.uk/pdbsum/2vaj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vaj ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/NCAM2_HUMAN NCAM2_HUMAN]] May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
+[https://www.uniprot.org/uniprot/NCAM2_HUMAN NCAM2_HUMAN] May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 14: / Line 14: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/va/2vaj_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 32: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Berezin, V]]
+[[Category: Large Structures]]
-[[Category: Bock, E]]
+[[Category: Berezin V]]
-[[Category: Gajhede, M]]
+[[Category: Bock E]]
-[[Category: Kastrup, J S]]
+[[Category: Gajhede M]]
-[[Category: Kristensen, O]]
+[[Category: Kastrup JS]]
-[[Category: Kulahin, N]]
+[[Category: Kristensen O]]
-[[Category: Navarro-Poulsen, J C]]
+[[Category: Kulahin N]]
-[[Category: Rasmussen, K K]]
+[[Category: Navarro-Poulsen J-C]]
-[[Category: Walmod, P S]]
+[[Category: Rasmussen KK]]
-[[Category: Cell adhesion]]
+[[Category: Walmod PS]]
-[[Category: Immunoglobulin domain]]

2vaj

From Proteopedia

Current revision

Crystal structure of NCAM2 Ig1 (I4122 cell unit)

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox