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2x1m

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==Crystal structure of Mycobacterium smegmatis methionyl-tRNA synthetase in complex with methionine==
==Crystal structure of Mycobacterium smegmatis methionyl-tRNA synthetase in complex with methionine==
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<StructureSection load='2x1m' size='340' side='right' caption='[[2x1m]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='2x1m' size='340' side='right'caption='[[2x1m]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2x1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2x1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X1M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene>, <scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x1l|2x1l]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene>, <scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1m OCA], [https://pdbe.org/2x1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x1m RCSB], [https://www.ebi.ac.uk/pdbsum/2x1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x1m ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1m OCA], [http://pdbe.org/2x1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x1m RCSB], [http://www.ebi.ac.uk/pdbsum/2x1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x1m ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0R3E2_MYCS2 A0R3E2_MYCS2]] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity).[SAAS:SAAS023457_004_015657][HAMAP-Rule:MF_01228]
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[https://www.uniprot.org/uniprot/A0R3E2_MYCS2 A0R3E2_MYCS2] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity).[SAAS:SAAS023457_004_015657][HAMAP-Rule:MF_01228]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2x1m" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2x1m" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Methionine--tRNA ligase]]
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[[Category: Large Structures]]
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[[Category: Mycs2]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Ingvarsson, H]]
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[[Category: Ingvarsson H]]
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[[Category: Jones, T A]]
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[[Category: Jones TA]]
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[[Category: Unge, T]]
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[[Category: Unge T]]
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[[Category: Aminoacyl-trna synthetase]]
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[[Category: Ligase]]
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[[Category: Nucleotide-binding]]
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[[Category: Protein biosynthesis]]
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Current revision

Crystal structure of Mycobacterium smegmatis methionyl-tRNA synthetase in complex with methionine

PDB ID 2x1m

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