4ux6
From Proteopedia
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==The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)== | ==The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)== | ||
| - | <StructureSection load='4ux6' size='340' side='right' caption='[[4ux6]], [[Resolution|resolution]] 3.00Å' scene=''> | + | <StructureSection load='4ux6' size='340' side='right'caption='[[4ux6]], [[Resolution|resolution]] 3.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UX6 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [https://pdbe.org/4ux6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ux6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ux6 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4ux6" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4ux6" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Andrews | + | [[Category: Mus musculus]] |
| - | [[Category: Beaton | + | [[Category: Andrews G]] |
| - | [[Category: Birkinshaw | + | [[Category: Beaton HG]] |
| - | [[Category: Boughton-Smith | + | [[Category: Birkinshaw T]] |
| - | [[Category: Cheshire | + | [[Category: Boughton-Smith N]] |
| - | [[Category: Connolly | + | [[Category: Cheshire DR]] |
| - | [[Category: Cook | + | [[Category: Connolly S]] |
| - | [[Category: Cooper | + | [[Category: Cook TR]] |
| - | [[Category: Cooper | + | [[Category: Cooper A]] |
| - | [[Category: Cox | + | [[Category: Cooper SL]] |
| - | [[Category: Dixon | + | [[Category: Cox D]] |
| - | [[Category: Gensmantel | + | [[Category: Dixon J]] |
| - | [[Category: Hamley | + | [[Category: Gensmantel N]] |
| - | [[Category: Harrison | + | [[Category: Hamley PJ]] |
| - | [[Category: Hartopp | + | [[Category: Harrison R]] |
| - | [[Category: Kack | + | [[Category: Hartopp P]] |
| - | [[Category: Luker | + | [[Category: Kack H]] |
| - | [[Category: Mete | + | [[Category: Luker T]] |
| - | [[Category: Millichip | + | [[Category: Mete A]] |
| - | [[Category: Nicholls | + | [[Category: Millichip I]] |
| - | [[Category: Pimm | + | [[Category: Nicholls DJ]] |
| - | [[Category: St-Gallay | + | [[Category: Pimm AD]] |
| - | [[Category: Wallace | + | [[Category: St-Gallay SA]] |
| - | + | [[Category: Wallace AV]] | |
| - | + | ||
Current revision
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)
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Categories: Large Structures | Mus musculus | Andrews G | Beaton HG | Birkinshaw T | Boughton-Smith N | Cheshire DR | Connolly S | Cook TR | Cooper A | Cooper SL | Cox D | Dixon J | Gensmantel N | Hamley PJ | Harrison R | Hartopp P | Kack H | Luker T | Mete A | Millichip I | Nicholls DJ | Pimm AD | St-Gallay SA | Wallace AV
