2deb

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[[Image:2deb.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221==
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|PDB= 2deb |SIZE=350|CAPTION= <scene name='initialview01'>2deb</scene>, resolution 1.60&Aring;
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<StructureSection load='2deb' size='340' side='right'caption='[[2deb]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>
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<table><tr><td colspan='2'>[[2deb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DEB FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2deb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2deb OCA], [https://pdbe.org/2deb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2deb RCSB], [https://www.ebi.ac.uk/pdbsum/2deb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2deb ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2fw3|2fw3]], [[2fyo|2fyo]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2deb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2deb OCA], [http://www.ebi.ac.uk/pdbsum/2deb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2deb RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CPT2_RAT CPT2_RAT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/2deb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2deb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.
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'''Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221'''
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A monotopic membrane protein goes solo.,Mattevi A Structure. 2006 Apr;14(4):628-9. PMID:16615901<ref>PMID:16615901</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2deb" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.
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*[[Carnitine palmitoyltransferase|Carnitine palmitoyltransferase]]
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== References ==
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==About this Structure==
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<references/>
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2DEB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DEB OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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A monotopic membrane protein goes solo., Mattevi A, Structure. 2006 Apr;14(4):628-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16615901 16615901]
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[[Category: Carnitine O-palmitoyltransferase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Banner DW]]
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[[Category: Banner, D W.]]
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[[Category: Benz J]]
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[[Category: Benz, J.]]
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[[Category: Chomienne O]]
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[[Category: Chomienne, O.]]
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[[Category: De Roo E]]
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[[Category: Gsell, B.]]
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[[Category: Gsell B]]
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[[Category: Hennig, M.]]
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[[Category: Hennig M]]
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[[Category: Mueller, F.]]
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[[Category: Mueller F]]
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[[Category: Roo, E De.]]
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[[Category: Rufer AC]]
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[[Category: Rufer, A C.]]
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[[Category: Stihle M]]
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[[Category: Stihle, M.]]
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[[Category: Thoma R]]
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[[Category: Thoma, R.]]
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[[Category: central six-stranded beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:33:34 2008''
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Current revision

Crystal structure of rat carnitine palmitoyltransferase 2 in space group C2221

PDB ID 2deb

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