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5foq

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==Acetylcholinesterase in complex with C7653==
==Acetylcholinesterase in complex with C7653==
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<StructureSection load='5foq' size='340' side='right' caption='[[5foq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='5foq' size='340' side='right'caption='[[5foq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5foq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FOQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FOQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5foq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FOQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GC8:2-(2,4-DICHLOROPHENOXY)-N-[4-(1-PIPERIDINYLMETHYL)PHENYL]ACETAMIDE'>GC8</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P15:2,5,8,11,14,17-HEXAOXANONADECAN-19-OL'>P15</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fpp|5fpp]], [[5fpq|5fpq]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GC8:2-(2,4-DICHLOROPHENOXY)-N-[4-(1-PIPERIDINYLMETHYL)PHENYL]ACETAMIDE'>GC8</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P15:2,5,8,11,14,17-HEXAOXANONADECAN-19-OL'>P15</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5foq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5foq OCA], [https://pdbe.org/5foq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5foq RCSB], [https://www.ebi.ac.uk/pdbsum/5foq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5foq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5foq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5foq OCA], [http://pdbe.org/5foq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5foq RCSB], [http://www.ebi.ac.uk/pdbsum/5foq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5foq ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acetylcholinesterase]]
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[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Andersson, D C]]
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[[Category: Andersson DC]]
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[[Category: Berg, L]]
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[[Category: Berg L]]
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[[Category: Ekstrom, F]]
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[[Category: Ekstrom F]]
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[[Category: Linusson, A]]
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[[Category: Linusson A]]
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[[Category: Mishra, B K]]
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[[Category: Mishra BK]]
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[[Category: Density functional theory]]
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[[Category: Drug design]]
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[[Category: Hydrolase]]
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[[Category: Quantum chemistry]]
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[[Category: Signaling protein]]
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Current revision

Acetylcholinesterase in complex with C7653

PDB ID 5foq

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