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| | ==NMR structure of the sea anemone peptide tau-AnmTx Ueq 12-1 with an uncommon fold== | | ==NMR structure of the sea anemone peptide tau-AnmTx Ueq 12-1 with an uncommon fold== |
| - | <StructureSection load='5lah' size='340' side='right' caption='[[5lah]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | + | <StructureSection load='5lah' size='340' side='right'caption='[[5lah]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5lah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Urticina_eques Urticina eques]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LAH FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5lah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Urticina_eques Urticina eques]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LAH FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lah OCA], [http://pdbe.org/5lah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lah RCSB], [http://www.ebi.ac.uk/pdbsum/5lah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lah ProSAT]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lah OCA], [https://pdbe.org/5lah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lah RCSB], [https://www.ebi.ac.uk/pdbsum/5lah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lah ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/TX121_URTEQ TX121_URTEQ] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| | + | [[Category: Large Structures]] |
| | [[Category: Urticina eques]] | | [[Category: Urticina eques]] |
| - | [[Category: Andreev, Y A]] | + | [[Category: Andreev YA]] |
| - | [[Category: Arseniev, A S]] | + | [[Category: Arseniev AS]] |
| - | [[Category: Kozlov, S A]] | + | [[Category: Kozlov SA]] |
| - | [[Category: Logashina, Y A]] | + | [[Category: Logashina YA]] |
| - | [[Category: Mineev, K S]] | + | [[Category: Mineev KS]] |
| - | [[Category: Antimicrobial peptide]]
| + | |
| - | [[Category: Membrane protein]]
| + | |
| - | [[Category: Protein]]
| + | |
| - | [[Category: Sea anemone]]
| + | |
| - | [[Category: Toxin]]
| + | |
| - | [[Category: Trpa1 potentiator]]
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| Structural highlights
Function
TX121_URTEQ
Publication Abstract from PubMed
A novel bioactive peptide named tau-AnmTx Ueq 12-1 (short name Ueq 12-1) was isolated and characterized from the sea anemone Urticina eques. Ueq 12-1 is unique among the variety of known sea anemone peptides in terms of its primary and spatial structure. It consists of 45 amino acids including 10 cysteine residues with an unusual distribution and represents a new group of sea anemone peptides. The 3D structure of Ueq 12-1, determined by NMR spectroscopy, represents a new disulfide-stabilized fold partly similar to the defensin-like fold. Ueq 12-1 showed the dual activity of both a moderate antibacterial activity against Gram-positive bacteria and a potentiating activity on the transient receptor potential ankyrin 1 (TRPA1). Ueq 12-1 is a unique peptide potentiator of the TRPA1 receptor that produces analgesic and anti-inflammatory effects in vivo. The antinociceptive properties allow us to consider Ueq 12-1 as a potential analgesic drug lead with antibacterial properties.
New Disulfide-Stabilized Fold Provides Sea Anemone Peptide to Exhibit Both Antimicrobial and TRPA1 Potentiating Properties.,Logashina YA, Solstad RG, Mineev KS, Korolkova YV, Mosharova IV, Dyachenko IA, Palikov VA, Palikova YA, Murashev AN, Arseniev AS, Kozlov SA, Stensvag K, Haug T, Andreev YA Toxins (Basel). 2017 Apr 29;9(5). pii: E154. doi: 10.3390/toxins9050154. PMID:28468269[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Logashina YA, Solstad RG, Mineev KS, Korolkova YV, Mosharova IV, Dyachenko IA, Palikov VA, Palikova YA, Murashev AN, Arseniev AS, Kozlov SA, Stensvag K, Haug T, Andreev YA. New Disulfide-Stabilized Fold Provides Sea Anemone Peptide to Exhibit Both Antimicrobial and TRPA1 Potentiating Properties. Toxins (Basel). 2017 Apr 29;9(5). pii: E154. doi: 10.3390/toxins9050154. PMID:28468269 doi:http://dx.doi.org/10.3390/toxins9050154
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