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6aqf

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Current revision (14:22, 4 October 2023) (edit) (undo)
 
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==Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris==
==Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris==
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<StructureSection load='6aqf' size='340' side='right' caption='[[6aqf]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
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<StructureSection load='6aqf' size='340' side='right'caption='[[6aqf]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6aqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AQF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6aqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AQF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZMA:4-{2-[(7-AMINO-2-FURAN-2-YL[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZIN-5-YL)AMINO]ETHYL}PHENOL'>ZMA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADORA2A, ADORA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZMA:4-{2-[(7-AMINO-2-FURAN-2-YL[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZIN-5-YL)AMINO]ETHYL}PHENOL'>ZMA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aqf OCA], [http://pdbe.org/6aqf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aqf RCSB], [http://www.ebi.ac.uk/pdbsum/6aqf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aqf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aqf OCA], [https://pdbe.org/6aqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aqf RCSB], [https://www.ebi.ac.uk/pdbsum/6aqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aqf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN]] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6aqf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6aqf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Adenosine A2A receptor 3D structures|Adenosine A2A receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Audet, M]]
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[[Category: Homo sapiens]]
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[[Category: Didenko, T]]
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[[Category: Large Structures]]
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[[Category: Eddy, M T]]
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[[Category: Audet M]]
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[[Category: Gao, Z]]
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[[Category: Didenko T]]
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[[Category: Han, G W]]
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[[Category: Eddy MT]]
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[[Category: Horst, R]]
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[[Category: Gao Z]]
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[[Category: Jacobson, K A]]
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[[Category: Han GW]]
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[[Category: Lee, M Y]]
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[[Category: Horst R]]
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[[Category: McClary, K M]]
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[[Category: Jacobson KA]]
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[[Category: Stanczak, P]]
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[[Category: Lee MY]]
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[[Category: Stevens, R C]]
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[[Category: McClary KM]]
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[[Category: White, K]]
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[[Category: Stanczak P]]
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[[Category: Wuthrich, K]]
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[[Category: Stevens RC]]
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[[Category: A2aar]]
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[[Category: White K]]
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[[Category: Adenosine receptor]]
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[[Category: Wuthrich K]]
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[[Category: Antagonist complex]]
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[[Category: Gpcr]]
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[[Category: Human a2aar_bril chimera]]
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[[Category: Lcp]]
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[[Category: Membrane protein]]
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[[Category: Pichia pastori]]
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Current revision

Crystal structure of A2AAR-BRIL in complex with the antagonist ZM241385 produced from Pichia pastoris

PDB ID 6aqf

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