1jup

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==Crystal structure of the multidrug binding transcriptional repressor QacR bound to malachite green==
==Crystal structure of the multidrug binding transcriptional repressor QacR bound to malachite green==
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<StructureSection load='1jup' size='340' side='right' caption='[[1jup]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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<StructureSection load='1jup' size='340' side='right'caption='[[1jup]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1jup]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1jup]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGR:MALACHITE+GREEN'>MGR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jt0|1jt0]], [[1jt6|1jt6]], [[1jtx|1jtx]], [[1jty|1jty]], [[1jum|1jum]], [[1jus|1jus]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGR:MALACHITE+GREEN'>MGR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jup OCA], [http://pdbe.org/1jup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jup RCSB], [http://www.ebi.ac.uk/pdbsum/1jup PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jup ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jup OCA], [https://pdbe.org/1jup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jup RCSB], [https://www.ebi.ac.uk/pdbsum/1jup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jup ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
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[https://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brennan, R G]]
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[[Category: Large Structures]]
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[[Category: Brown, M H]]
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[[Category: Staphylococcus aureus]]
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[[Category: Grkovic, S]]
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[[Category: Brennan RG]]
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[[Category: Miller, M C]]
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[[Category: Brown MH]]
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[[Category: Schumacher, M A]]
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[[Category: Grkovic S]]
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[[Category: Skurray, R A]]
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[[Category: Miller MC]]
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[[Category: Malachite green]]
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[[Category: Schumacher MA]]
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[[Category: Multidrug binding protein]]
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[[Category: Skurray RA]]
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[[Category: Multidrug recognition]]
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[[Category: Qacr]]
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[[Category: Transcription]]
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Current revision

Crystal structure of the multidrug binding transcriptional repressor QacR bound to malachite green

PDB ID 1jup

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