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| | ==Minimized average structure of MTH1880 from Methanobacterium Thermoautotrophicum== | | ==Minimized average structure of MTH1880 from Methanobacterium Thermoautotrophicum== |
| - | <StructureSection load='1iqs' size='340' side='right' caption='[[1iqs]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | + | <StructureSection load='1iqs' size='340' side='right'caption='[[1iqs]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1iqs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"methanobacterium_thermoautotrophicus"_(sic)_zeikus_and_wolfe_1972 "methanobacterium thermoautotrophicus" (sic) zeikus and wolfe 1972]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IQS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1iqs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IQS FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1iqo|1iqo]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iqs OCA], [http://pdbe.org/1iqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iqs RCSB], [http://www.ebi.ac.uk/pdbsum/1iqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1iqs ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iqs OCA], [https://pdbe.org/1iqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iqs RCSB], [https://www.ebi.ac.uk/pdbsum/1iqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iqs ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/O27908_METTH O27908_METTH] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Arrowsmith, C H]] | + | [[Category: Large Structures]] |
| - | [[Category: Bang, E]] | + | [[Category: Methanothermobacter thermautotrophicus]] |
| - | [[Category: Jung, J W]] | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Lee, C H]] | + | [[Category: Bang E]] |
| - | [[Category: Lee, W]] | + | [[Category: Jung JW]] |
| - | [[Category: Shin, J]] | + | [[Category: Lee CH]] |
| - | [[Category: Yee, A]] | + | [[Category: Lee W]] |
| - | [[Category: Alpha-beta]] | + | [[Category: Shin J]] |
| - | [[Category: Anti-parallel]] | + | [[Category: Yee A]] |
| - | [[Category: Metal binding protein]]
| + | |
| Structural highlights
Function
O27908_METTH
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
MTH1880 is a hypothetical protein from Methanobacterium thermoautotrophicum, a target organism of structural genomics. The solution structure determined by NMR spectroscopy demonstrates a typical alpha + beta-fold found in many proteins with different functions. The molecular surface of the protein reveals a small, highly acidic pocket comprising loop B (Asp36, Asp37, Asp38), the end of beta2 (Glu39), and loop D (Ser57, Ser58, Ser61), indicating that the protein would have a possible cation binding site. The NMR resonances of several amino acids within the acidic binding pocket in MTH1880, shifted upon addition of calcium ion. This calcium binding motif and overall topology of MTH1880 differ from those of other calcium binding proteins. MTH1880 did not show a calcium-induced conformational change typical of calcium sensor proteins. Therefore, we propose that the MTH1880 protein contains a novel motif for calcium-specific binding, and may function as a calcium buffering protein.
Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum.,Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W Protein Sci. 2004 Apr;13(4):1148-54. PMID:15044740[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W. Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum. Protein Sci. 2004 Apr;13(4):1148-54. PMID:15044740 doi:10.1110/ps.03472104
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