2dis

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[[Image:2dis.gif|left|200px]]
 
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{{Structure
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==Solution structure of the RRM domain of unnamed protein product==
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|PDB= 2dis |SIZE=350|CAPTION= <scene name='initialview01'>2dis</scene>
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<StructureSection load='2dis' size='340' side='right'caption='[[2dis]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2dis]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DIS FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dis OCA], [https://pdbe.org/2dis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dis RCSB], [https://www.ebi.ac.uk/pdbsum/2dis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dis ProSAT], [https://www.topsan.org/Proteins/RSGI/2dis TOPSAN]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dis OCA], [http://www.ebi.ac.uk/pdbsum/2dis PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dis RCSB]</span>
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[https://www.uniprot.org/uniprot/RBM47_HUMAN RBM47_HUMAN] Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing (PubMed:24038582, PubMed:24916387, PubMed:27050523, PubMed:30844405, PubMed:31358901, PubMed:34160127). Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules (PubMed:24038582, PubMed:24916387, PubMed:30844405). Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10 (PubMed:34160127). Also involved in the alternative splicing of several genes including TJP1. Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs (PubMed:27050523, PubMed:31358901). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity).[UniProtKB:A0A8M1NHK4]<ref>PMID:24038582</ref> <ref>PMID:24916387</ref> <ref>PMID:27050523</ref> <ref>PMID:30844405</ref> <ref>PMID:31358901</ref> <ref>PMID:34160127</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Solution structure of the RRM domain of unnamed protein product'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/2dis_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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2DIS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIS OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dis ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dang, W.]]
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[[Category: Dang W]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y.]]
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[[Category: Muto Y]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M.]]
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[[Category: Terada T]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nmr]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rrm domain]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:35:09 2008''
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Current revision

Solution structure of the RRM domain of unnamed protein product

PDB ID 2dis

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OCA

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