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2diz
From Proteopedia
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| - | [[Image:2diz.gif|left|200px]] | ||
| - | + | ==The solution structure of the third thioredoxin domain of human Thioredoxin domain-containing protein 5== | |
| - | + | <StructureSection load='2diz' size='340' side='right'caption='[[2diz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2diz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DIZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DIZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TXNDC5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |
| - | | | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2diz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2diz OCA], [https://pdbe.org/2diz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2diz RCSB], [https://www.ebi.ac.uk/pdbsum/2diz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2diz ProSAT], [https://www.topsan.org/Proteins/RSGI/2diz TOPSAN]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [[https://www.uniprot.org/uniprot/TXND5_HUMAN TXND5_HUMAN]] Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/di/2diz_consurf.spt"</scriptWhenChecked> | |
| - | == | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | [[Category: | + | </jmolCheckbox> |
| - | [[Category: | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2diz ConSurf]. |
| - | [[Category: Inoue, M | + | <div style="clear:both"></div> |
| - | [[Category: Kigawa, T | + | __TOC__ |
| - | [[Category: Koshiba, S | + | </StructureSection> |
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Tochio, N | + | [[Category: Large Structures]] |
| - | [[Category: Yokoyama, S | + | [[Category: Inoue, M]] |
| - | [[Category: | + | [[Category: Kigawa, T]] |
| - | [[Category: | + | [[Category: Koshiba, S]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Tochio, N]] |
| - | [[Category: | + | [[Category: Yokoyama, S]] |
| - | + | [[Category: Electron transport]] | |
| - | + | [[Category: Endoplasmic reticulum protein erp46]] | |
| - | [[Category: | + | [[Category: National project on protein structural and functional analyse]] |
| - | + | [[Category: Nppsfa]] | |
| - | + | [[Category: Rsgi]] | |
| + | [[Category: Thioredoxin-like protein p46]] | ||
| + | [[Category: Tlp46]] | ||
Current revision
The solution structure of the third thioredoxin domain of human Thioredoxin domain-containing protein 5
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