6bxr

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'''Unreleased structure'''
 
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The entry 6bxr is ON HOLD until Paper Publication
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==Crystal structure of Toxoplasma gondii Mitochondrial Association Factor 1 B (MAF1B)==
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<StructureSection load='6bxr' size='340' side='right'caption='[[6bxr]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors: Parker, M.L., Ramaswamy, R., Boulanger, M.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6bxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BXR FirstGlance]. <br>
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Description: Crystal structure of Toxoplasma gondii Mitochondrial Association Factor 1 B (MAF1B)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Ramaswamy, R]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxr OCA], [https://pdbe.org/6bxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bxr RCSB], [https://www.ebi.ac.uk/pdbsum/6bxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxr ProSAT]</span></td></tr>
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[[Category: Parker, M.L]]
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</table>
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[[Category: Boulanger, M.J]]
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== Function ==
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[https://www.uniprot.org/uniprot/MAFB1_TOXGO MAFB1_TOXGO] During host cell infection by tachyzoites, required for tethering the parasitophorous vacuole to the host mitochondria (PubMed:26920761, PubMed:24781109, PubMed:28567444, PubMed:33723040, PubMed:35025629, PubMed:29505111). This process, known as host mitochondrial association (HMA), induces the formation of SPOTs (structures positive for outer mitochondrial membrane (OMM)), a cellular response to OMM stress, which leads to the constitutive shedding of OMM vesicles containing proteins such as mitofusins MFN1 and MFN2, which normally restrict parasite growth (PubMed:35025629). Specifically, binds to the host OMM import receptor TOMM70 to interact with SAMM50, a component of host mitochondrial intermembrane space bridging (MIB) complex (PubMed:28567444, PubMed:33723040, PubMed:35025629). By targeting SAMM50, induces the disassembly of the MIB complex, thereby promoting the formation of SPOTs (PubMed:35025629). Inhibits host TOMM70 import activity (PubMed:35025629). Plays a role in the modulation of the host innate immune response to parasite infection (PubMed:24781109, PubMed:30333181).<ref>PMID:24781109</ref> <ref>PMID:26920761</ref> <ref>PMID:28567444</ref> <ref>PMID:29505111</ref> <ref>PMID:30333181</ref> <ref>PMID:33723040</ref> <ref>PMID:35025629</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Toxoplasma gondii]]
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[[Category: Boulanger MJ]]
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[[Category: Parker ML]]
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[[Category: Ramaswamy R]]

Current revision

Crystal structure of Toxoplasma gondii Mitochondrial Association Factor 1 B (MAF1B)

PDB ID 6bxr

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