6c6k

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m (Protected "6c6k" [edit=sysop:move=sysop])
Current revision (14:32, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6c6k is ON HOLD
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==Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex==
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<StructureSection load='6c6k' size='340' side='right'caption='[[6c6k]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
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Authors: Amarasinghe, G.K., Leung, D.W., Johnson, B., Xu, W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6c6k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Equine_encephalosis_virus Equine encephalosis virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C6K FirstGlance]. <br>
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Description: Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Leung, D.W]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6k OCA], [https://pdbe.org/6c6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c6k RCSB], [https://www.ebi.ac.uk/pdbsum/6c6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6k ProSAT]</span></td></tr>
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[[Category: Johnson, B]]
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</table>
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[[Category: Amarasinghe, G.K]]
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== Function ==
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[[Category: Xu, W]]
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[https://www.uniprot.org/uniprot/IFIT1_HUMAN IFIT1_HUMAN] Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.<ref>PMID:19008854</ref> <ref>PMID:19416887</ref> <ref>PMID:21976647</ref> <ref>PMID:23334420</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Equine encephalosis virus]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Amarasinghe GK]]
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[[Category: Johnson B]]
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[[Category: Leung DW]]
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[[Category: Xu W]]

Current revision

Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex

PDB ID 6c6k

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