5x0t
From Proteopedia
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==Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody 6H8== | ==Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody 6H8== | ||
| - | <StructureSection load='5x0t' size='340' side='right' caption='[[5x0t]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='5x0t' size='340' side='right'caption='[[5x0t]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5x0t]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X0T OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5x0t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X0T FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x0t OCA], [https://pdbe.org/5x0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x0t RCSB], [https://www.ebi.ac.uk/pdbsum/5x0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x0t ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BASI_HUMAN BASI_HUMAN] Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.<ref>PMID:17127621</ref> |
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| + | ==See Also== | ||
| + | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | ||
| + | *[[3D structures of basigin|3D structures of basigin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Chen X]] |
| - | [[Category: | + | [[Category: Chen Z-N]] |
| - | [[Category: | + | [[Category: Lin P]] |
| - | [[Category: | + | [[Category: Ye S]] |
| - | [[Category: | + | [[Category: Yu X-L]] |
| - | [[Category: | + | [[Category: Zhang M-Y]] |
| - | [[Category: | + | [[Category: Zhang R-G]] |
| - | [[Category: | + | [[Category: Zhu P]] |
Current revision
Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody 6H8
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Categories: Homo sapiens | Large Structures | Mus musculus | Chen X | Chen Z-N | Lin P | Ye S | Yu X-L | Zhang M-Y | Zhang R-G | Zhu P
