6b3y

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==Crystal structure of the PH-like domain from DENND3==
==Crystal structure of the PH-like domain from DENND3==
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<StructureSection load='6b3y' size='340' side='right' caption='[[6b3y]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='6b3y' size='340' side='right'caption='[[6b3y]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6b3y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B3Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6b3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B3Y FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b3y OCA], [http://pdbe.org/6b3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b3y RCSB], [http://www.ebi.ac.uk/pdbsum/6b3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b3y ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.852&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b3y OCA], [https://pdbe.org/6b3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b3y RCSB], [https://www.ebi.ac.uk/pdbsum/6b3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b3y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DEND3_MOUSE DEND3_MOUSE]] Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation (PubMed:24719330, PubMed:25925668, PubMed:28249939). Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12 (PubMed:25925668). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:21718402, PubMed:24719330). Starvation also induces phosphorylation at Tyr-940, which leads to up-regulated GEF activity and initiates autophagy (PubMed:28249939).<ref>PMID:21718402</ref> <ref>PMID:24719330</ref> <ref>PMID:25925668</ref> <ref>PMID:28249939</ref>
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[https://www.uniprot.org/uniprot/DEND3_MOUSE DEND3_MOUSE] Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation (PubMed:24719330, PubMed:25925668, PubMed:28249939). Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12 (PubMed:25925668). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:21718402, PubMed:24719330). Starvation also induces phosphorylation at Tyr-940, which leads to up-regulated GEF activity and initiates autophagy (PubMed:28249939).<ref>PMID:21718402</ref> <ref>PMID:24719330</ref> <ref>PMID:25925668</ref> <ref>PMID:28249939</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beaugrand, M]]
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[[Category: Large Structures]]
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[[Category: Gehring, K]]
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[[Category: Mus musculus]]
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[[Category: Kozlov, G]]
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[[Category: Beaugrand M]]
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[[Category: McPherson, P S]]
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[[Category: Gehring K]]
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[[Category: Menade, M]]
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[[Category: Kozlov G]]
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[[Category: Pan, T]]
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[[Category: McPherson PS]]
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[[Category: Xu, J]]
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[[Category: Menade M]]
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[[Category: Autophagy]]
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[[Category: Pan T]]
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[[Category: Guanine nucleotide exchange factor]]
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[[Category: Xu J]]
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[[Category: Ph-like fold]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of the PH-like domain from DENND3

PDB ID 6b3y

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