1h6h

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==Structure of the PX domain from p40phox bound to phosphatidylinositol 3-phosphate==
==Structure of the PX domain from p40phox bound to phosphatidylinositol 3-phosphate==
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<StructureSection load='1h6h' size='340' side='right' caption='[[1h6h]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='1h6h' size='340' side='right'caption='[[1h6h]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1h6h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H6H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1h6h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H6H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PIB:2-(BUTANOYLOXY)-1-{[(HYDROXY{[2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL)OXY]METHYL}ETHYL+BUTANOATE'>PIB</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h6h OCA], [http://pdbe.org/1h6h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h6h RCSB], [http://www.ebi.ac.uk/pdbsum/1h6h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h6h ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PIB:2-(BUTANOYLOXY)-1-{[(HYDROXY{[2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL)OXY]METHYL}ETHYL+BUTANOATE'>PIB</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h6h OCA], [https://pdbe.org/1h6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h6h RCSB], [https://www.ebi.ac.uk/pdbsum/1h6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h6h ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/NCF4_HUMAN NCF4_HUMAN]] Defects in NCF4 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 3 (CGD3) [MIM:[http://omim.org/entry/613960 613960]]. CGD3 is a disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:19692703</ref>
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[https://www.uniprot.org/uniprot/NCF4_HUMAN NCF4_HUMAN] Defects in NCF4 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 3 (CGD3) [MIM:[https://omim.org/entry/613960 613960]. CGD3 is a disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:19692703</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NCF4_HUMAN NCF4_HUMAN]] Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
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[https://www.uniprot.org/uniprot/NCF4_HUMAN NCF4_HUMAN] Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1h6h" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1h6h" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[NADPH oxidase 3D structures|NADPH oxidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bravo, J]]
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[[Category: Large Structures]]
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[[Category: Karathanassis, D]]
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[[Category: Bravo J]]
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[[Category: Pacold, M]]
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[[Category: Karathanassis D]]
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[[Category: Perisic, O]]
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[[Category: Pacold M]]
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[[Category: Williams, R L]]
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[[Category: Perisic O]]
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[[Category: Px domain]]
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[[Category: Williams RL]]

Current revision

Structure of the PX domain from p40phox bound to phosphatidylinositol 3-phosphate

PDB ID 1h6h

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