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2gse
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==Crystal Structure of Human Dihydropyrimidinease-like 2== | ==Crystal Structure of Human Dihydropyrimidinease-like 2== | ||
| - | <StructureSection load='2gse' size='340' side='right' caption='[[2gse]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='2gse' size='340' side='right'caption='[[2gse]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2gse]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2gse]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GSE FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gse OCA], [https://pdbe.org/2gse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gse RCSB], [https://www.ebi.ac.uk/pdbsum/2gse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gse ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DPYL2_HUMAN DPYL2_HUMAN] Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.<ref>PMID:11477421</ref> <ref>PMID:15466863</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gse ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gse ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Axonal growth cone guidance is a central process in nervous system development and repair. Collapsin response mediator protein 2 (CRMP-2) is a neurite extension-promoting neuronal cytosolic molecule involved in the signalling of growth inhibitory cues from external stimuli, such as semaphorin 3A and the myelin-associated glycoprotein. We have determined the crystal structure of human tetrameric CRMP-2, which is structurally related to the dihydropyriminidases; however, the active site is not conserved. The wealth of earlier functional mapping data for CRMP-2 are discussed in light of the three-dimensional structure of the protein. The differences in oligomerisation interfaces between CRMP-1 and CRMP-2 are used to model CRMP-1/2 heterotetramers. | ||
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| - | The structure of human collapsin response mediator protein 2, a regulator of axonal growth.,Stenmark P, Ogg D, Flodin S, Flores A, Kotenyova T, Nyman T, Nordlund P, Kursula P J Neurochem. 2007 May;101(4):906-17. Epub 2007 Jan 22. PMID:17250651<ref>PMID:17250651</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2gse" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | + | [[Category: Berglund H]] | |
| - | [[Category: Berglund | + | [[Category: Collins R]] |
| - | [[Category: Collins | + | [[Category: Edwards A]] |
| - | [[Category: Edwards | + | [[Category: Ehn M]] |
| - | [[Category: Ehn | + | [[Category: Flodin S]] |
| - | [[Category: Flodin | + | [[Category: Flores A]] |
| - | [[Category: Flores | + | [[Category: Graslund S]] |
| - | [[Category: Graslund | + | [[Category: Hallberg BM]] |
| - | [[Category: Hallberg | + | [[Category: Hammarstrom M]] |
| - | [[Category: Hammarstrom | + | [[Category: Holmberg-Schiavone L]] |
| - | [[Category: Holmberg-Schiavone | + | [[Category: Kotenyova T]] |
| - | [[Category: Kotenyova | + | [[Category: Kursula P]] |
| - | [[Category: Kursula | + | [[Category: Nilsson-Ehle P]] |
| - | [[Category: Nilsson-Ehle | + | [[Category: Nordlund P]] |
| - | [[Category: Nordlund | + | [[Category: Nyman T]] |
| - | [[Category: Nyman | + | [[Category: Ogg D]] |
| - | [[Category: Ogg | + | [[Category: Persson C]] |
| - | [[Category: Persson | + | [[Category: Sagemark J]] |
| - | + | [[Category: Stenmark P]] | |
| - | [[Category: Sagemark | + | [[Category: Sundstrom M]] |
| - | [[Category: Stenmark | + | [[Category: Thorsell AG]] |
| - | [[Category: Sundstrom | + | [[Category: Uppenberg J]] |
| - | [[Category: Thorsell | + | [[Category: Van Den Berg S]] |
| - | [[Category: Uppenberg | + | [[Category: Weigelt J]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
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Current revision
Crystal Structure of Human Dihydropyrimidinease-like 2
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Berglund H | Collins R | Edwards A | Ehn M | Flodin S | Flores A | Graslund S | Hallberg BM | Hammarstrom M | Holmberg-Schiavone L | Kotenyova T | Kursula P | Nilsson-Ehle P | Nordlund P | Nyman T | Ogg D | Persson C | Sagemark J | Stenmark P | Sundstrom M | Thorsell AG | Uppenberg J | Van Den Berg S | Weigelt J
