This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2x4d
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
==Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP== | ==Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP== | ||
| - | <StructureSection load='2x4d' size='340' side='right' caption='[[2x4d]], [[Resolution|resolution]] 1.92Å' scene=''> | + | <StructureSection load='2x4d' size='340' side='right'caption='[[2x4d]], [[Resolution|resolution]] 1.92Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2x4d]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2x4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4D FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4d OCA], [https://pdbe.org/2x4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4d RCSB], [https://www.ebi.ac.uk/pdbsum/2x4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4d ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LHPP_HUMAN LHPP_HUMAN] Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 19: | Line 22: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Allerston C]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi C]] |
| - | [[Category: Guo | + | [[Category: Guo K]] |
| - | [[Category: Kavanagh | + | [[Category: Kavanagh KL]] |
| - | [[Category: Muniz | + | [[Category: Muniz JRC]] |
| - | [[Category: Oppermann | + | [[Category: Oppermann U]] |
| - | [[Category: Savitsky | + | [[Category: Savitsky P]] |
| - | [[Category: Vollmar | + | [[Category: Vollmar M]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Yue | + | [[Category: Yue W]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
Current revision
Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP
| |||||||||||
Categories: Homo sapiens | Large Structures | Allerston C | Arrowsmith CH | Bountra C | Edwards A | Gileadi C | Guo K | Kavanagh KL | Muniz JRC | Oppermann U | Savitsky P | Vollmar M | Weigelt J | Yue W | Von Delft F
