2x4f

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==The Crystal Structure of the human myosin light chain kinase LOC340156.==
==The Crystal Structure of the human myosin light chain kinase LOC340156.==
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<StructureSection load='2x4f' size='340' side='right' caption='[[2x4f]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
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<StructureSection load='2x4f' size='340' side='right'caption='[[2x4f]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2x4f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2x4f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16X:4-(2-AMINO-4-METHYL-1,3-THIAZOL-5-YL)-N-(3-DIOXAZIRIDIN-3-YLPHENYL)PYRIMIDIN-2-AMINE'>16X</scene>, <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16X:4-(2-AMINO-4-METHYL-1,3-THIAZOL-5-YL)-N-(3-DIOXAZIRIDIN-3-YLPHENYL)PYRIMIDIN-2-AMINE'>16X</scene>, <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4f OCA], [http://pdbe.org/2x4f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4f RCSB], [http://www.ebi.ac.uk/pdbsum/2x4f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4f ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4f OCA], [https://pdbe.org/2x4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4f RCSB], [https://www.ebi.ac.uk/pdbsum/2x4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4f ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYLK4_HUMAN MYLK4_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x4f ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x4f ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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==See Also==
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*[[Myosin light chain kinase|Myosin light chain kinase]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Chaikuad, A]]
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[[Category: Chaikuad A]]
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[[Category: Cocking, R]]
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[[Category: Cocking R]]
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[[Category: Daga, N]]
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[[Category: Daga N]]
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[[Category: Delft, F von]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M]]
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[[Category: Fedorov O]]
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[[Category: Fedorov, O]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Mahajan P]]
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[[Category: Mahajan, P]]
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[[Category: Muniz JRC]]
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[[Category: Muniz, J R.C]]
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[[Category: Rellos P]]
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[[Category: Rellos, P]]
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[[Category: Shrestha B]]
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[[Category: Shrestha, B]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E]]
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[[Category: Wang J]]
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[[Category: Wang, J]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Yue W]]
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[[Category: Yue, W]]
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[[Category: Von Delft F]]
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[[Category: Breast cancer]]
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[[Category: Kinase]]
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[[Category: Lung]]
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[[Category: Myosin]]
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[[Category: Transferase]]
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Current revision

The Crystal Structure of the human myosin light chain kinase LOC340156.

PDB ID 2x4f

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