2xvc

From Proteopedia

(Difference between revisions)

Current revision

Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division

Structural highlights

2xvc is a 2 chain structure with sequence from Saccharolobus solfataricus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.15Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q97ZJ6_SACS2

Publication Abstract from PubMed

Members of the crenarchaeal kingdom, such as Sulfolobus, divide by binary fission yet lack genes for the otherwise near-ubiquitous tubulin and actin superfamilies of cytoskeletal proteins. Recent work has established that Sulfolobus homologs of the eukaryotic ESCRT-III and Vps4 components of the ESCRT machinery play an important role in Sulfolobus cell division. In eukaryotes, several pathways recruit ESCRT-III proteins to their sites of action. However, the positioning determinants for archaeal ESCRT-III are not known. Here, we identify a protein, CdvA, that is responsible for recruiting Sulfolobus ESCRT-III to membranes. Overexpression of the isolated ESCRT-III domain that interacts with CdvA results in the generation of nucleoid-free cells. Furthermore, CdvA and ESCRT-III synergize to deform archaeal membranes in vitro. The structure of the CdvA/ESCRT-III interface gives insight into the evolution of the more complex and modular eukaryotic ESCRT complex.

Molecular and Structural Basis of ESCRT-III Recruitment to Membranes during Archaeal Cell Division.,Samson RY, Obita T, Hodgson B, Shaw MK, Chong PL, Williams RL, Bell SD Mol Cell. 2011 Jan 21;41(2):186-96. PMID:21255729^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Samson RY, Obita T, Hodgson B, Shaw MK, Chong PL, Williams RL, Bell SD. Molecular and Structural Basis of ESCRT-III Recruitment to Membranes during Archaeal Cell Division. Mol Cell. 2011 Jan 21;41(2):186-96. PMID:21255729 doi:10.1016/j.molcel.2010.12.018

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2xvc"

@@ Line 1: / Line 1: @@
 ==Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division==
-<StructureSection load='2xvc' size='340' side='right' caption='[[2xvc]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+<StructureSection load='2xvc' size='340' side='right'caption='[[2xvc]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2xvc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XVC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2xvc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVC FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvc OCA], [http://pdbe.org/2xvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xvc RCSB], [http://www.ebi.ac.uk/pdbsum/2xvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvc ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvc OCA], [https://pdbe.org/2xvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvc RCSB], [https://www.ebi.ac.uk/pdbsum/2xvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvc ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q97ZJ6_SACS2 Q97ZJ6_SACS2]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 23: @@
 __TOC__
 </StructureSection>
-[[Category: Atcc 35091]]
+[[Category: Large Structures]]
-[[Category: Bell, S D]]
+[[Category: Saccharolobus solfataricus]]
-[[Category: Chong, P L]]
+[[Category: Bell SD]]
-[[Category: Hodgson, B]]
+[[Category: Chong PL]]
-[[Category: Obita, T]]
+[[Category: Hodgson B]]
-[[Category: Samson, R Y]]
+[[Category: Obita T]]
-[[Category: Shaw, M K]]
+[[Category: Samson RY]]
-[[Category: Williams, R L]]
+[[Category: Shaw MK]]
-[[Category: Cell cycle]]
+[[Category: Williams RL]]
-[[Category: Cell division]]
-[[Category: Cytokinesis]]
-[[Category: Winged-helix]]

2xvc

From Proteopedia

Current revision

Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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