4c8d
From Proteopedia
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==Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)== | ==Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)== | ||
| - | <StructureSection load='4c8d' size='340' side='right' caption='[[4c8d]], [[Resolution|resolution]] 2.18Å' scene=''> | + | <StructureSection load='4c8d' size='340' side='right'caption='[[4c8d]], [[Resolution|resolution]] 2.18Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4c8d]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4c8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C8D FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8d OCA], [https://pdbe.org/4c8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c8d RCSB], [https://www.ebi.ac.uk/pdbsum/4c8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8d ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KDM3B_HUMAN KDM3B_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.<ref>PMID:16603237</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Crawley L]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi C]] |
| - | [[Category: Goubin | + | [[Category: Goubin S]] |
| - | [[Category: Johansson | + | [[Category: Johansson C]] |
| - | [[Category: Krojer | + | [[Category: Krojer T]] |
| - | [[Category: Oppermann | + | [[Category: Oppermann U]] |
| - | [[Category: Szykowska | + | [[Category: Szykowska A]] |
| - | [[Category: Vollmar | + | [[Category: Vollmar M]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
Current revision
Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Crawley L | Edwards A | Gileadi C | Goubin S | Johansson C | Krojer T | Oppermann U | Szykowska A | Vollmar M | Von Delft F
