4jii

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==Crystal Structure Of AKR1B10 Complexed With NADP+ And Zopolrestat==
==Crystal Structure Of AKR1B10 Complexed With NADP+ And Zopolrestat==
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<StructureSection load='4jii' size='340' side='right' caption='[[4jii]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='4jii' size='340' side='right'caption='[[4jii]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jii]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JII FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jii]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JII FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZST:3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE+ACETIC+ACID'>ZST</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gqg|4gqg]], [[4gq0|4gq0]], [[4jih|4jih]], [[4jir|4jir]], [[4i5x|4i5x]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZST:3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE+ACETIC+ACID'>ZST</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1B10, AKR1B11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jii OCA], [https://pdbe.org/4jii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jii RCSB], [https://www.ebi.ac.uk/pdbsum/4jii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jii ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jii OCA], [http://pdbe.org/4jii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jii RCSB], [http://www.ebi.ac.uk/pdbsum/4jii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jii ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN]] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
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[https://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4jii" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4jii" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aldo-keto reductase 3D structures|Aldo-keto reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Chen, K]]
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[[Category: Large Structures]]
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[[Category: Hu, X]]
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[[Category: Chen K]]
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[[Category: Structural genomic]]
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[[Category: Hu X]]
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[[Category: Zhai, J]]
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[[Category: Zhai J]]
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[[Category: Zhang, H]]
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[[Category: Zhang H]]
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[[Category: Zhang, L]]
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[[Category: Zhang L]]
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[[Category: Zhao, Y]]
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[[Category: Zhao Y]]
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[[Category: Zheng, X]]
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[[Category: Zheng X]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Sgc]]
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[[Category: Tim barrel]]
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Current revision

Crystal Structure Of AKR1B10 Complexed With NADP+ And Zopolrestat

PDB ID 4jii

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