5tcm

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Current revision (12:57, 4 October 2023) (edit) (undo)
 
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==First Bromodomain from Leishmania donovani LdBPK.091320 complexed with BI-2536==
==First Bromodomain from Leishmania donovani LdBPK.091320 complexed with BI-2536==
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<StructureSection load='5tcm' size='340' side='right' caption='[[5tcm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='5tcm' size='340' side='right'caption='[[5tcm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5tcm]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Leidb Leidb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TCM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TCM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5tcm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_donovani_BPK282A1 Leishmania donovani BPK282A1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TCM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=R78:4-{[(7R)-8-CYCLOPENTYL-7-ETHYL-5-METHYL-6-OXO-5,6,7,8-TETRAHYDROPTERIDIN-2-YL]AMINO}-3-METHOXY-N-(1-METHYLPIPERIDIN-4-YL)BENZAMIDE'>R78</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tck|5tck]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=R78:4-{[(7R)-8-CYCLOPENTYL-7-ETHYL-5-METHYL-6-OXO-5,6,7,8-TETRAHYDROPTERIDIN-2-YL]AMINO}-3-METHOXY-N-(1-METHYLPIPERIDIN-4-YL)BENZAMIDE'>R78</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LDBPK_091320 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=981087 LEIDB])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tcm OCA], [https://pdbe.org/5tcm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tcm RCSB], [https://www.ebi.ac.uk/pdbsum/5tcm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tcm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tcm OCA], [http://pdbe.org/5tcm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tcm RCSB], [http://www.ebi.ac.uk/pdbsum/5tcm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tcm ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A3Q8I8I6_LEIDO A0A3Q8I8I6_LEIDO]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Leidb]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Leishmania donovani BPK282A1]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Dong, A]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M]]
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[[Category: Dong A]]
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[[Category: Hou, C F.D]]
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[[Category: Edwards AM]]
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[[Category: Hui, R]]
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[[Category: Hou CFD]]
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[[Category: Lin, Y H]]
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[[Category: Hui R]]
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[[Category: Loppnau, P]]
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[[Category: Lin YH]]
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[[Category: Structural genomic]]
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[[Category: Loppnau P]]
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[[Category: Walker, J R]]
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[[Category: Walker JR]]
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[[Category: Bromodomain]]
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[[Category: Inhibitor]]
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[[Category: Unknown function]]
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Current revision

First Bromodomain from Leishmania donovani LdBPK.091320 complexed with BI-2536

PDB ID 5tcm

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