2dth

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[[Image:2dth.jpg|left|200px]]
 
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{{Structure
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==The Crystal Structure of the Orthorhombic Form of Biotin Protein Ligase From Pyrococcus Horikoshii OT3 in Complex with Biotin and ADP==
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|PDB= 2dth |SIZE=350|CAPTION= <scene name='initialview01'>2dth</scene>, resolution 1.95&Aring;
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<StructureSection load='2dth' size='340' side='right'caption='[[2dth]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BTN:BIOTIN'>BTN</scene>
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<table><tr><td colspan='2'>[[2dth]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DTH FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Biotin--[acetyl-CoA-carboxylase]_ligase Biotin--[acetyl-CoA-carboxylase] ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.15 6.3.4.15] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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|GENE= birA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BTN:BIOTIN'>BTN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dth OCA], [https://pdbe.org/2dth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dth RCSB], [https://www.ebi.ac.uk/pdbsum/2dth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dth ProSAT], [https://www.topsan.org/Proteins/RSGI/2dth TOPSAN]</span></td></tr>
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|RELATEDENTRY=[[1wnl|1WNL]], [[1wpy|1WPY]], [[1wq7|1WQ7]], [[1wqw|1WQW]], [[1x01|1X01]], [[2fyk|2FYK]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dth OCA], [http://www.ebi.ac.uk/pdbsum/2dth PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dth RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/O57883_PYRHO O57883_PYRHO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/2dth_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dth ConSurf].
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<div style="clear:both"></div>
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'''The Crystal Structure of the Orthorhombic Form of Biotin Protein Ligase From Pyrococcus Horikoshii OT3 in Complex with Biotin and ADP'''
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==See Also==
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*[[Biotin Protein Ligase 3D structures|Biotin Protein Ligase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2DTH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DTH OCA].
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[[Category: Large Structures]]
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[[Category: Biotin--[acetyl-CoA-carboxylase] ligase]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Pyrococcus horikoshii]]
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[[Category: Bagautdinov B]]
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[[Category: Single protein]]
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[[Category: Kunishima N]]
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[[Category: Bagautdinov, B.]]
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[[Category: Kunishima, N.]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: biotin biosynthesis]]
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[[Category: dimer]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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[[Category: x-ray diffraction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:39:14 2008''
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Current revision

The Crystal Structure of the Orthorhombic Form of Biotin Protein Ligase From Pyrococcus Horikoshii OT3 in Complex with Biotin and ADP

PDB ID 2dth

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