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1l8l

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==Molecular basis for the local confomational rearrangement of human phosphoserine phosphatase==
==Molecular basis for the local confomational rearrangement of human phosphoserine phosphatase==
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<StructureSection load='1l8l' size='340' side='right' caption='[[1l8l]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
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<StructureSection load='1l8l' size='340' side='right'caption='[[1l8l]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1l8l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L8L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1l8l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L8L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APO:D-2-AMINO-3-PHOSPHONO-PROPIONIC+ACID'>APO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l8o|1l8o]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APO:D-2-AMINO-3-PHOSPHONO-PROPIONIC+ACID'>APO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoserine_phosphatase Phosphoserine phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.3 3.1.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8l OCA], [https://pdbe.org/1l8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l8l RCSB], [https://www.ebi.ac.uk/pdbsum/1l8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8l ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8l OCA], [http://pdbe.org/1l8l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l8l RCSB], [http://www.ebi.ac.uk/pdbsum/1l8l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8l ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN]] Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:[http://omim.org/entry/614023 614023]]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.<ref>PMID:14673469</ref>
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[https://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN] Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:[https://omim.org/entry/614023 614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.<ref>PMID:14673469</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN]] Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.<ref>PMID:12777757</ref>
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[https://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN] Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.<ref>PMID:12777757</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1l8l" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1l8l" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphoserine phosphatase|Phosphoserine phosphatase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Phosphoserine phosphatase]]
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[[Category: Large Structures]]
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[[Category: Heo, Y S]]
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[[Category: Heo YS]]
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[[Category: Hwang, K Y]]
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[[Category: Hwang KY]]
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[[Category: Jeon, Y H]]
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[[Category: Jeon YH]]
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[[Category: Kim, H Y]]
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[[Category: Kim HY]]
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[[Category: Kim, J H]]
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[[Category: Kim JH]]
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[[Category: Lee, T G]]
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[[Category: Lee TG]]
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[[Category: Moon, J]]
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[[Category: Moon J]]
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[[Category: Park, M H]]
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[[Category: Park MH]]
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[[Category: Park, S Y]]
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[[Category: Park SY]]
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[[Category: Ro, S]]
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[[Category: Ro S]]
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[[Category: Conformational rearrangement]]
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[[Category: Hydrolase]]
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[[Category: Phosphatase]]
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Current revision

Molecular basis for the local confomational rearrangement of human phosphoserine phosphatase

PDB ID 1l8l

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