Sandbox Reserved 1431
From Proteopedia
(Difference between revisions)
(→Crystal structure of the µ-opioid receptor bound to a morphinan antagonist) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 6: | Line 6: | ||
<StructureSection load='' size='340' side='right' caption='Click a green link on the left to load Figure 1' scene=''> | <StructureSection load='' size='340' side='right' caption='Click a green link on the left to load Figure 1' scene=''> | ||
'''Figure 1: Overall view of the µ-OR structure''' | '''Figure 1: Overall view of the µ-OR structure''' | ||
| + | see [https://www.nature.com/articles/nature10954 the paper] for essentially this exact figure. | ||
| + | |||
Shown in <jmol><jmollink><text>Figure 1</text><script>exit;figure="http://proteopedia.org/wiki/images/2/20/Nature10954Fig1aLeft_4dkl-2.png";SCRIPT @figure</script></jmollink></jmol> is an overall view of the µ-opioid receptor bound to the morphinan antagonist ([https://chemapps.stolaf.edu/jmol/jmol.php?pdbid=BF0&script=set%20echo%20top%20left;echo%20PDBid%20BF0;spin%20on PDBid BF0]). The seven parallel trans-membrane helices are the signature of a "TM7" cell membrane receptor, spanning the 35-40 nm distance across the lipid bilayer of the cell. | Shown in <jmol><jmollink><text>Figure 1</text><script>exit;figure="http://proteopedia.org/wiki/images/2/20/Nature10954Fig1aLeft_4dkl-2.png";SCRIPT @figure</script></jmollink></jmol> is an overall view of the µ-opioid receptor bound to the morphinan antagonist ([https://chemapps.stolaf.edu/jmol/jmol.php?pdbid=BF0&script=set%20echo%20top%20left;echo%20PDBid%20BF0;spin%20on PDBid BF0]). The seven parallel trans-membrane helices are the signature of a "TM7" cell membrane receptor, spanning the 35-40 nm distance across the lipid bilayer of the cell. | ||
| Line 14: | Line 16: | ||
Investigate the structure after loading the <jmol><jmollink><text>Figure 1 model</text><script>exit;SCRIPT "http://proteopedia.org/wiki/images/2/20/Nature10954Fig1aLeft_4dkl-2.png"</script></jmollink></jmol> by dragging it around using your mouse or clicking the buttons below. SHIFT-drag to zoom. | Investigate the structure after loading the <jmol><jmollink><text>Figure 1 model</text><script>exit;SCRIPT "http://proteopedia.org/wiki/images/2/20/Nature10954Fig1aLeft_4dkl-2.png"</script></jmollink></jmol> by dragging it around using your mouse or clicking the buttons below. SHIFT-drag to zoom. | ||
| - | <jmol><jmollink><text>(a) exocellular view</text><script>SCRIPT http://proteopedia.org/wiki/images/0/00/Nature10954_fig1d.spt('top')</script></jmollink></jmol> | + | <jmol><jmollink><text>(a) exocellular view</text><script>if (!figure){figure="http://proteopedia.org/wiki/images/2/20/Nature10954Fig1aLeft_4dkl-2.png";SCRIPT @figure}; SCRIPT http://proteopedia.org/wiki/images/0/00/Nature10954_fig1d.spt('top')</script></jmollink></jmol> |
| - | <jmol><jmollink><text>(b) endocellular</text><script>SCRIPT http://proteopedia.org/wiki/images/0/00/Nature10954_fig1d.spt('bottom')</script></jmollink></jmol> | + | <jmol><jmollink><text>(b) endocellular</text><script>if (!figure){figure="http://proteopedia.org/wiki/images/2/20/Nature10954Fig1aLeft_4dkl-2.png";SCRIPT @figure};SCRIPT http://proteopedia.org/wiki/images/0/00/Nature10954_fig1d.spt('bottom')</script></jmollink></jmol> |
| - | <jmol><jmollink><text>(c) trans-membrane view</text><script>SCRIPT http://proteopedia.org/wiki/images/0/00/Nature10954_fig1d.spt('side')</script></jmollink></jmol> | + | <jmol><jmollink><text>(c) trans-membrane view</text><script>if (!figure){figure="http://proteopedia.org/wiki/images/2/20/Nature10954Fig1aLeft_4dkl-2.png";SCRIPT @figure};SCRIPT http://proteopedia.org/wiki/images/0/00/Nature10954_fig1d.spt('side')</script></jmollink></jmol> |
| - | <jmol><jmollink><text>(d) trans-membrane view with abstract membrane</text><script>SCRIPT http://proteopedia.org/wiki/images/0/00/Nature10954_fig1d.spt('draw')</script></jmollink></jmol> | + | <jmol><jmollink><text>(d) trans-membrane view with abstract membrane</text><script>if (!figure){figure="http://proteopedia.org/wiki/images/2/20/Nature10954Fig1aLeft_4dkl-2.png";SCRIPT @figure};SCRIPT http://proteopedia.org/wiki/images/0/00/Nature10954_fig1d.spt('draw')</script></jmollink></jmol> |
</StructureSection> | </StructureSection> | ||
| - | <jmol><jmollink><text>Animate Figure 1a</text><script>script "http://proteopedia.org/wiki/images/1/1f/Nature10954_fig1a.spt"</script></jmollink></jmol> | ||
| - | + | BELOW THIS LINE IS NOT PART OF THE ACTUAL PAGE | |
| + | |||
code for the above (space inserted just after the : <code><jmol><jmollink><text>View Figure 1a: Overall view of the µ-OR structure</text><script>exit;figure=1;SCRIPT "/wiki/images/8/8b/4dkl-local-contact.png"</script></jmollink></jmol></code> | code for the above (space inserted just after the : <code><jmol><jmollink><text>View Figure 1a: Overall view of the µ-OR structure</text><script>exit;figure=1;SCRIPT "/wiki/images/8/8b/4dkl-local-contact.png"</script></jmollink></jmol></code> | ||
| + | |||
| + | <jmol><jmollink><text>Animate Figure 1a</text><script>script "http://proteopedia.org/wiki/images/1/1f/Nature10954_fig1a.spt"</script></jmollink></jmol> | ||
| + | |||
Current revision
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
[https://www.nature.com/articles/nature10954 Nature volume 485, pages 321–326 (17 May 2012) doi:10.1038/nature10954]
| |||||||||||
BELOW THIS LINE IS NOT PART OF THE ACTUAL PAGE
code for the above (space inserted just after the : <jmol><jmollink><text>View Figure 1a: Overall view of the µ-OR structure</text><script>exit;figure=1;SCRIPT "/wiki/images/8/8b/4dkl-local-contact.png"</script></jmollink></jmol>
is a close-up view of a bound to the µ-opioid receptor. The green circles indicate hydrogen bonds.
