2dzb

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[[Image:2dzb.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in complex with 6HMPPP==
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|PDB= 2dzb |SIZE=350|CAPTION= <scene name='initialview01'>2dzb</scene>, resolution 1.90&Aring;
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<StructureSection load='2dzb' size='340' side='right'caption='[[2dzb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=HH2:6-HYDROXYMETHYLPTERIN-DIPHOSPHATE'>HH2</scene>
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<table><tr><td colspan='2'>[[2dzb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DZB FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE= FolP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HH2:6-HYDROXYMETHYLPTERIN-DIPHOSPHATE'>HH2</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dzb OCA], [https://pdbe.org/2dzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dzb RCSB], [https://www.ebi.ac.uk/pdbsum/2dzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dzb ProSAT], [https://www.topsan.org/Proteins/RSGI/2dzb TOPSAN]</span></td></tr>
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|RELATEDENTRY=[[2dqw|2DQW]], [[2dza|2DZA]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dzb OCA], [http://www.ebi.ac.uk/pdbsum/2dzb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dzb RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q5SLV2_THET8 Q5SLV2_THET8] DHPS catalyzes the formation of the immediate precursor of folic acid.[RuleBase:RU361205]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dz/2dzb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dzb ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in complex with 6HMPPP'''
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==See Also==
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*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2DZB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZB OCA].
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[[Category: Large Structures]]
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[[Category: Dihydropteroate synthase]]
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[[Category: Single protein]]
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[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Bagautdinov, B.]]
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[[Category: Bagautdinov B]]
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[[Category: Kunishima, N.]]
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[[Category: Kunishima N]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: 6hmppp]]
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[[Category: dihydropteroate synthase]]
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[[Category: dimer]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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[[Category: x-ray diffraction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:41:31 2008''
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Current revision

Crystal Structure of Dihydropteroate Synthase from Thermus thermophilus HB8 in complex with 6HMPPP

PDB ID 2dzb

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