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2e0z

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[[Image:2e0z.gif|left|200px]]
 
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{{Structure
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==Crystal structure of virus-like particle from Pyrococcus furiosus==
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|PDB= 2e0z |SIZE=350|CAPTION= <scene name='initialview01'>2e0z</scene>, resolution 3.60&Aring;
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<StructureSection load='2e0z' size='340' side='right'caption='[[2e0z]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2e0z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E0Z FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e0z OCA], [https://pdbe.org/2e0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e0z RCSB], [https://www.ebi.ac.uk/pdbsum/2e0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e0z ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e0z OCA], [http://www.ebi.ac.uk/pdbsum/2e0z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2e0z RCSB]</span>
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[https://www.uniprot.org/uniprot/ENCP1_PYRFU ENCP1_PYRFU] Fusion of the shell and cargo protein of a type 1 encapsulin nanocompartment (PubMed:17397865). The nanocompartment is probably involved in iron storage (Probable). Expression in E.coli generates spherical particles (PfSPs) about 30 nm in diameter (PubMed:16091594).<ref>PMID:16091594</ref> <ref>PMID:17397865</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/2e0z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e0z ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of virus-like particle from Pyrococcus furiosus'''
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==See Also==
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*[[Art:Faberge Eggs|Art:Faberge Eggs]]
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== References ==
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==Overview==
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<references/>
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Pyrococcus furiosus is a hyperthermophilic archaeal microorganism found near deep-sea thermal vents and its optimal growth temperature of 100 degrees C. Recently, a 38.8-kDa protein from P. furiosus DSM 3638 was isolated and characterized. Electron microscopy revealed that this protein aggregated as spheres of approximately 30 nm in diameter, which we designated P. furiosus virus-like particles (PfVs). X-ray crystallographic analysis at 3.6-A resolution revealed that each PfV consisted of 180 copies of the 38.8-kDa protein and retained T=3 icosahedral symmetry, as is often the case in spherical viruses. The total molecular mass of each particle was approximately 7 MDa. An examination of capsid structures suggested strong evolutionary links among PfV, tailed double-stranded DNA bacteriophages, and herpes viruses. The similar three-dimensional structures of the various coat proteins indicate that these viral capsids might have originated and evolved from a common ancestor. The structure of PfV provides a previously undescribed example of viral relationships across the three domains of life (Eukarya, Bacteria, and Archaea).
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2E0Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E0Z OCA].
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==Reference==
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The crystal structure of a virus-like particle from the hyperthermophilic archaeon Pyrococcus furiosus provides insight into the evolution of viruses., Akita F, Chong KT, Tanaka H, Yamashita E, Miyazaki N, Nakaishi Y, Suzuki M, Namba K, Ono Y, Tsukihara T, Nakagawa A, J Mol Biol. 2007 May 18;368(5):1469-83. Epub 2007 Mar 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17397865 17397865]
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[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
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[[Category: Single protein]]
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[[Category: Akita F]]
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[[Category: Akita, F.]]
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[[Category: Chong KT]]
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[[Category: Chong, K T.]]
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[[Category: Miyazaki N]]
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[[Category: Miyazaki, N.]]
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[[Category: Nakagawa A]]
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[[Category: Nakagawa, A.]]
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[[Category: Nakaishi Y]]
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[[Category: Nakaishi, Y.]]
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[[Category: Namba K]]
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[[Category: Namba, K.]]
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[[Category: Ono Y]]
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[[Category: Ono, Y.]]
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[[Category: Suzuki M]]
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[[Category: Suzuki, M.]]
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[[Category: Tanaka H]]
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[[Category: Tanaka, H.]]
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[[Category: Tsukihara T]]
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[[Category: Tsukihara, T.]]
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[[Category: Yamashita E]]
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[[Category: Yamashita, E.]]
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[[Category: bacteriophage]]
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[[Category: hk97]]
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[[Category: t4]]
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[[Category: virus]]
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[[Category: virus-like particle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:42:09 2008''
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Current revision

Crystal structure of virus-like particle from Pyrococcus furiosus

PDB ID 2e0z

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