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| - | | + | #REDIRECT [[6cm4]] This PDB entry is obsolete and replaced by 6cm4 |
| - | ==Structure of the D2 Dopamine Receptor Bound to the Atypical Antipsychotic Drug Risperidone==
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| - | <StructureSection load='6c38' size='340' side='right' caption='[[6c38]], [[Resolution|resolution]] 2.87Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[6c38]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C38 FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8NU:3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one'>8NU</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c38 OCA], [http://pdbe.org/6c38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c38 RCSB], [http://www.ebi.ac.uk/pdbsum/6c38 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c38 ProSAT]</span></td></tr>
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| - | </table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/DRD2_HUMAN DRD2_HUMAN]] Myoclonic dystonia 11. The gene represented in this entry may be involved in disease pathogenesis. DRD2 mutations in myoclonic dystonia patients are rare, and their contribution to disease phenotype is unclear (PubMed:10716258).
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/DRD2_HUMAN DRD2_HUMAN]] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity).<ref>PMID:21645528</ref> <ref>PMID:17264214</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Lysozyme]]
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| - | [[Category: Che, T]]
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| - | [[Category: Levit, A]]
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| - | [[Category: Roth, B L]]
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| - | [[Category: Shoichet, B K]]
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| - | [[Category: Wacker, D]]
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| - | [[Category: Wang, S]]
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| - | [[Category: Antipsychotic]]
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| - | [[Category: D2]]
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| - | [[Category: Dopamine receptor]]
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| - | [[Category: Gpcr]]
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| - | [[Category: Membrane protein]]
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| - | [[Category: Risperidone]]
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