1tjy

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==Crystal Structure of Salmonella typhimurium AI-2 receptor LsrB in complex with R-THMF==
==Crystal Structure of Salmonella typhimurium AI-2 receptor LsrB in complex with R-THMF==
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<StructureSection load='1tjy' size='340' side='right' caption='[[1tjy]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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<StructureSection load='1tjy' size='340' side='right'caption='[[1tjy]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1tjy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TJY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1tjy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TJY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAV:(2R,4S)-2-METHYL-2,3,3,4-TETRAHYDROXYTETRAHYDROFURAN'>PAV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jx6|1jx6]], [[1tm2|1tm2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PAV:(2R,4S)-2-METHYL-2,3,3,4-TETRAHYDROXYTETRAHYDROFURAN'>PAV</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LsrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjy OCA], [https://pdbe.org/1tjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tjy RCSB], [https://www.ebi.ac.uk/pdbsum/1tjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tjy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tjy OCA], [http://pdbe.org/1tjy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tjy RCSB], [http://www.ebi.ac.uk/pdbsum/1tjy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tjy ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LSRB_SALTI LSRB_SALTI]] Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity).
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[https://www.uniprot.org/uniprot/LSRB_SALTY LSRB_SALTY] Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable).<ref>PMID:11722742</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tj/1tjy_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tj/1tjy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Salty]]
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[[Category: Large Structures]]
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[[Category: Bassler, B L]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Campagna, S R]]
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[[Category: Bassler BL]]
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[[Category: Hughson, F M]]
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[[Category: Campagna SR]]
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[[Category: Miller, S T]]
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[[Category: Hughson FM]]
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[[Category: Semmelhack, M F]]
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[[Category: Miller ST]]
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[[Category: Taga, M E]]
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[[Category: Semmelhack MF]]
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[[Category: Xavier, K B]]
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[[Category: Taga ME]]
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[[Category: Protein-ligand complex]]
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[[Category: Xavier KB]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of Salmonella typhimurium AI-2 receptor LsrB in complex with R-THMF

PDB ID 1tjy

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