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3b7w

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==Crystal structure of human acyl-CoA synthetase medium-chain family member 2A, with L64P mutation==
==Crystal structure of human acyl-CoA synthetase medium-chain family member 2A, with L64P mutation==
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<StructureSection load='3b7w' size='340' side='right' caption='[[3b7w]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3b7w' size='340' side='right'caption='[[3b7w]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3b7w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B7W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3b7w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B7W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACSM2A, ACSM2, MACS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Butyrate--CoA_ligase Butyrate--CoA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.2.1.2 6.2.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7w OCA], [https://pdbe.org/3b7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b7w RCSB], [https://www.ebi.ac.uk/pdbsum/3b7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7w ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7w OCA], [http://pdbe.org/3b7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b7w RCSB], [http://www.ebi.ac.uk/pdbsum/3b7w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7w ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACS2A_HUMAN ACS2A_HUMAN]] Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).
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[https://www.uniprot.org/uniprot/ACS2A_HUMAN ACS2A_HUMAN] Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Butyrate--CoA ligase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Delft, F von]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Kochan GT]]
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[[Category: Kochan, G T]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W]]
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[[Category: Pilka ES]]
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[[Category: Pilka, E S]]
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[[Category: Weigelt J]]
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[[Category: Structural genomic]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J]]
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[[Category: Atp-binding]]
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[[Category: Fatty acid metabolism]]
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[[Category: Ligase]]
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[[Category: Lipid metabolism]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Middle-chain acyl-coa synthetase]]
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[[Category: Mitochondrion]]
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[[Category: Nucleotide-binding]]
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[[Category: Sgc]]
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[[Category: Transit peptide]]
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[[Category: Xenobiotic/medium-chain fatty acid-coa ligase]]
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Current revision

Crystal structure of human acyl-CoA synthetase medium-chain family member 2A, with L64P mutation

PDB ID 3b7w

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