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| | ==Crystal Structure of Fab CR9114== | | ==Crystal Structure of Fab CR9114== |
| - | <StructureSection load='4fqh' size='340' side='right' caption='[[4fqh]], [[Resolution|resolution]] 2.05Å' scene=''> | + | <StructureSection load='4fqh' size='340' side='right'caption='[[4fqh]], [[Resolution|resolution]] 2.05Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4fqh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQH FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4fqh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQH FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fnk|4fnk]], [[4fqi|4fqi]], [[4fqj|4fqj]], [[4fqk|4fqk]], [[4fql|4fql]], [[4fqm|4fqm]], [[4fqv|4fqv]], [[4fqy|4fqy]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqh OCA], [http://pdbe.org/4fqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fqh RCSB], [http://www.ebi.ac.uk/pdbsum/4fqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqh ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqh OCA], [https://pdbe.org/4fqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqh RCSB], [https://www.ebi.ac.uk/pdbsum/4fqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqh ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
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| | </div> | | </div> |
| | <div class="pdbe-citations 4fqh" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 4fqh" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Antibody 3D structures|Antibody 3D structures]] |
| | + | *[[Sandbox 20009|Sandbox 20009]] |
| | + | *[[3D structures of human antibody|3D structures of human antibody]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| - | [[Category: Dreyfus, C]] | + | [[Category: Large Structures]] |
| - | [[Category: Wilson, I A]] | + | [[Category: Dreyfus C]] |
| - | [[Category: Antibody affinity]] | + | [[Category: Wilson IA]] |
| - | [[Category: Antigen]]
| + | |
| - | [[Category: Epitope]]
| + | |
| - | [[Category: Glycosylation]]
| + | |
| - | [[Category: Hemagglutinin glycoprotein]]
| + | |
| - | [[Category: Immune system]]
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| - | [[Category: Immunoglobulin fab fragment]]
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| - | [[Category: Influenza vaccine]]
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| - | [[Category: Influenza virus]]
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| - | [[Category: Membrane fusion]]
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| - | [[Category: Neutralizing antibody]]
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| Structural highlights
Publication Abstract from PubMed
Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a significant part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses.
Highly Conserved Protective Epitopes on Influenza B Viruses.,Dreyfus C, Laursen NS, Kwaks T, Zuijdgeest D, Khayat R, Ekiert DC, Lee JH, Metlagel Z, Bujny MV, Jongeneelen M, van der Vlugt R, Lamrani M, Korse HJ, Geelen E, Sahin O, Sieuwerts M, Brakenhoff JP, Vogels R, Li OT, Poon LL, Peiris M, Koudstaal W, Ward AB, Wilson IA, Goudsmit J, Friesen RH Science. 2012 Aug 9. PMID:22878502[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Dreyfus C, Laursen NS, Kwaks T, Zuijdgeest D, Khayat R, Ekiert DC, Lee JH, Metlagel Z, Bujny MV, Jongeneelen M, van der Vlugt R, Lamrani M, Korse HJ, Geelen E, Sahin O, Sieuwerts M, Brakenhoff JP, Vogels R, Li OT, Poon LL, Peiris M, Koudstaal W, Ward AB, Wilson IA, Goudsmit J, Friesen RH. Highly Conserved Protective Epitopes on Influenza B Viruses. Science. 2012 Aug 9. PMID:22878502 doi:10.1126/science.1222908
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