4q23
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==The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates== | ==The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates== | ||
| - | <StructureSection load='4q23' size='340' side='right' caption='[[4q23]], [[Resolution|resolution]] 1.98Å' scene=''> | + | <StructureSection load='4q23' size='340' side='right'caption='[[4q23]], [[Resolution|resolution]] 1.98Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4q23]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4q23]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q23 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q23 OCA], [https://pdbe.org/4q23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q23 RCSB], [https://www.ebi.ac.uk/pdbsum/4q23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q23 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. |
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| + | ==See Also== | ||
| + | *[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Barnett BL]] |
| - | [[Category: Dunford | + | [[Category: Dunford JE]] |
| - | [[Category: Ebetino | + | [[Category: Ebetino FH]] |
| - | [[Category: Evdokimov | + | [[Category: Evdokimov A]] |
| - | [[Category: Kavanagh | + | [[Category: Kavanagh KL]] |
| - | [[Category: Kwaasi | + | [[Category: Kwaasi AA]] |
| - | [[Category: Muniz | + | [[Category: Muniz JRC]] |
| - | [[Category: Oppermann | + | [[Category: Oppermann U]] |
| - | [[Category: Pilka | + | [[Category: Pilka ES]] |
| - | [[Category: Russell | + | [[Category: Russell RGG]] |
| - | [[Category: Tsoumpra | + | [[Category: Tsoumpra MK]] |
| - | [[Category: Walter | + | [[Category: Walter RL]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
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Current revision
The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
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Categories: Homo sapiens | Large Structures | Barnett BL | Dunford JE | Ebetino FH | Evdokimov A | Kavanagh KL | Kwaasi AA | Muniz JRC | Oppermann U | Pilka ES | Russell RGG | Tsoumpra MK | Walter RL | Von Delft F
